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Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I

There is a critical need for therapeutic approaches that combine renewable sources of replacement beta cells with localized immunomodulation to counter recurrence of autoimmunity in type 1 diabetes (T1D). However, there are few examples of animal models to study such approaches that incorporate spon...

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Detalles Bibliográficos
Autores principales:	Santini-González, Jorge, Castro-Gutierrez, Roberto, Becker, Matthew W., Rancourt, Chad, Russ, Holger A., Phelps, Edward A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732725/ https://www.ncbi.nlm.nih.gov/pubmed/36506044 http://dx.doi.org/10.3389/fendo.2022.989815

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