Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity

When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action...

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Autores principales: Huang, Shanzhi, Cheng, Anchun, Wang, Mingshu, Yin, Zhongqiong, Huang, Juan, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732732/
https://www.ncbi.nlm.nih.gov/pubmed/36505476
http://dx.doi.org/10.3389/fimmu.2022.1065211
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author Huang, Shanzhi
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Huang, Juan
Jia, Renyong
author_facet Huang, Shanzhi
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Huang, Juan
Jia, Renyong
author_sort Huang, Shanzhi
collection PubMed
description When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action between ubiquitination and proteins in these signal cascades enhances the antiviral signal. On the contrary, more and more viruses have also been found to use the ubiquitination system to inhibit TLR/RLR mediated innate immunity. Therefore, this review summarizes how the ubiquitination system plays a regulatory role in TLR/RLR mediated innate immunity, and how viruses use the ubiquitination system to complete immune escape.
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spelling pubmed-97327322022-12-10 Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity Huang, Shanzhi Cheng, Anchun Wang, Mingshu Yin, Zhongqiong Huang, Juan Jia, Renyong Front Immunol Immunology When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action between ubiquitination and proteins in these signal cascades enhances the antiviral signal. On the contrary, more and more viruses have also been found to use the ubiquitination system to inhibit TLR/RLR mediated innate immunity. Therefore, this review summarizes how the ubiquitination system plays a regulatory role in TLR/RLR mediated innate immunity, and how viruses use the ubiquitination system to complete immune escape. Frontiers Media S.A. 2022-11-25 /pmc/articles/PMC9732732/ /pubmed/36505476 http://dx.doi.org/10.3389/fimmu.2022.1065211 Text en Copyright © 2022 Huang, Cheng, Wang, Yin, Huang and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Shanzhi
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Huang, Juan
Jia, Renyong
Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title_full Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title_fullStr Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title_full_unstemmed Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title_short Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
title_sort viruses utilize ubiquitination systems to escape tlr/rlr-mediated innate immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732732/
https://www.ncbi.nlm.nih.gov/pubmed/36505476
http://dx.doi.org/10.3389/fimmu.2022.1065211
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