DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers

We have developed a transition-metal free protocol for efficient cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones and toluenes/phenols using DTBP as an oxidant. A diverse range of 3-aryl benzofuran-2(3H)-ones, toluenes, and phenols undergo C–H bond cleavage to generate all-carbon quate...

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Detalles Bibliográficos
Autores principales: Tong, Zhou, Peng, Xinju, Tang, Zhi, Yang, Weijun, Deng, Wei, Yin, Shuang-Feng, Kambe, Nobuaki, Qiu, Renhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732748/
https://www.ncbi.nlm.nih.gov/pubmed/36540229
http://dx.doi.org/10.1039/d2ra06231c
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author Tong, Zhou
Peng, Xinju
Tang, Zhi
Yang, Weijun
Deng, Wei
Yin, Shuang-Feng
Kambe, Nobuaki
Qiu, Renhua
author_facet Tong, Zhou
Peng, Xinju
Tang, Zhi
Yang, Weijun
Deng, Wei
Yin, Shuang-Feng
Kambe, Nobuaki
Qiu, Renhua
author_sort Tong, Zhou
collection PubMed
description We have developed a transition-metal free protocol for efficient cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones and toluenes/phenols using DTBP as an oxidant. A diverse range of 3-aryl benzofuran-2(3H)-ones, toluenes, and phenols undergo C–H bond cleavage to generate all-carbon quaternary centers in good yields, making this protocol useful for the synthesis of complex molecules. A gram scale experiment was performed in good yield.
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spelling pubmed-97327482022-12-19 DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers Tong, Zhou Peng, Xinju Tang, Zhi Yang, Weijun Deng, Wei Yin, Shuang-Feng Kambe, Nobuaki Qiu, Renhua RSC Adv Chemistry We have developed a transition-metal free protocol for efficient cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones and toluenes/phenols using DTBP as an oxidant. A diverse range of 3-aryl benzofuran-2(3H)-ones, toluenes, and phenols undergo C–H bond cleavage to generate all-carbon quaternary centers in good yields, making this protocol useful for the synthesis of complex molecules. A gram scale experiment was performed in good yield. The Royal Society of Chemistry 2022-12-09 /pmc/articles/PMC9732748/ /pubmed/36540229 http://dx.doi.org/10.1039/d2ra06231c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tong, Zhou
Peng, Xinju
Tang, Zhi
Yang, Weijun
Deng, Wei
Yin, Shuang-Feng
Kambe, Nobuaki
Qiu, Renhua
DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title_full DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title_fullStr DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title_full_unstemmed DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title_short DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
title_sort dtbp-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3h)-ones with toluenes/phenols for all-carbon quaternary centers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732748/
https://www.ncbi.nlm.nih.gov/pubmed/36540229
http://dx.doi.org/10.1039/d2ra06231c
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