Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2

Topoisomerase 1 (Top1) incises DNA containing ribonucleotides to generate complex DNA lesions that are resolved by APE2 (Apn2 in yeast). How Apn2 engages and processes this DNA damage is unclear. Here, we report X-ray crystal structures and biochemical analysis of Apn2-DNA complexes to demonstrate h...

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Detalles Bibliográficos
Autores principales: Williams, Jessica S., Wojtaszek, Jessica L., Appel, Denise C., Krahn, Juno, Wallace, Bret D., Walsh, Evan, Kunkel, Thomas A., Williams, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732815/
https://www.ncbi.nlm.nih.gov/pubmed/36198268
http://dx.doi.org/10.1016/j.celrep.2022.111448

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