Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

[Image: see text] Alzheimer’s disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated drug targets. Accumulating evidence now suggests that they...

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Detalles Bibliográficos
Autores principales: Gandini, Annachiara, Gonçalves, Ana Elisa, Strocchi, Silvia, Albertini, Claudia, Janočková, Jana, Tramarin, Anna, Grifoni, Daniela, Poeta, Eleonora, Soukup, Ondrej, Muñoz-Torrero, Diego, Monti, Barbara, Sabaté, Raimon, Bartolini, Manuela, Legname, Giuseppe, Bolognesi, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732823/
https://www.ncbi.nlm.nih.gov/pubmed/36445009
http://dx.doi.org/10.1021/acschemneuro.2c00357

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