Direct Access to Unnatural Cyclobutane α-Amino Acids through Visible Light Catalyzed [2+2]-Cycloaddition

[Image: see text] In this work, we report the first selective, photocatalyzed [2+2]-cycloaddition of dehydroamino acids with styrene-type olefins. This simple, mild, and scalable approach relies on the use of the triplet energy transfer catalyst [Ir(dFCF(3)ppy(2))dtbpy]PF(6) under visible light irra...

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Detalles Bibliográficos
Autores principales: Stinglhamer, Martin, Yzeiri, Xheila, Rohlfs, Tabea, Brandhofer, Tobias, Daniliuc, Constantin G., García Mancheño, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732878/
https://www.ncbi.nlm.nih.gov/pubmed/36510614
http://dx.doi.org/10.1021/acsorginorgau.2c00026
Descripción
Sumario:[Image: see text] In this work, we report the first selective, photocatalyzed [2+2]-cycloaddition of dehydroamino acids with styrene-type olefins. This simple, mild, and scalable approach relies on the use of the triplet energy transfer catalyst [Ir(dFCF(3)ppy(2))dtbpy]PF(6) under visible light irradiation and provides fast access to value-added substituted strained cyclobutane α-amino acid derivatives.

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