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Functionalized aliphatic polyketones with germicide activity

The COVID-19 pandemic has further confirmed to the community that direct contact with contaminated surfaces and objects represents an important source of pathogen spreading among humans. Therefore, it is of paramount importance to design effective germicidal paints to ensure a rapid and potent disin...

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Autores principales: Araya-Hermosilla, Esteban, Parlanti, Paola, Gemmi, Mauro, Mattoli, Virgilio, Di Pietro, Sebastiano, Iacopini, Dalila, Granchi, Carlotta, Turchi, Barbara, Fratini, Filippo, Di Bussolo, Valeria, Minutolo, Filippo, Picchioni, Francesco, Pucci, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732932/
https://www.ncbi.nlm.nih.gov/pubmed/36540247
http://dx.doi.org/10.1039/d2ra06396d
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author Araya-Hermosilla, Esteban
Parlanti, Paola
Gemmi, Mauro
Mattoli, Virgilio
Di Pietro, Sebastiano
Iacopini, Dalila
Granchi, Carlotta
Turchi, Barbara
Fratini, Filippo
Di Bussolo, Valeria
Minutolo, Filippo
Picchioni, Francesco
Pucci, Andrea
author_facet Araya-Hermosilla, Esteban
Parlanti, Paola
Gemmi, Mauro
Mattoli, Virgilio
Di Pietro, Sebastiano
Iacopini, Dalila
Granchi, Carlotta
Turchi, Barbara
Fratini, Filippo
Di Bussolo, Valeria
Minutolo, Filippo
Picchioni, Francesco
Pucci, Andrea
author_sort Araya-Hermosilla, Esteban
collection PubMed
description The COVID-19 pandemic has further confirmed to the community that direct contact with contaminated surfaces and objects represents an important source of pathogen spreading among humans. Therefore, it is of paramount importance to design effective germicidal paints to ensure a rapid and potent disinfectant action of surfaces. In this work, we design novel germicide polymeric coatings by inserting quaternary ammonium and sugar groups on the macromolecular backbone, thus respectively endowing the polymer with germicide features and hydrophilicity to interact with the surfaces. An aliphatic polyketone was selected as a starting polymer matrix that was functionalized with primary amine derivatives via the Paal–Knorr reaction. The resulting polymers were deposited on cellulose filter papers and checkboard charts with excellent coating yield and substrate coverage as determined by scanning electron microscopy for cellulose. Remarkably, the substrates coated by the functional polymers bearing quaternary ammonium compounds showed excellent bactericide properties with antibacterial rate of 99% and logarithmic reduction of >3. Notably, the polymers with higher hydrophobicity showed better retention on the substrate after being treated with water at neutral pH.
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spelling pubmed-97329322022-12-19 Functionalized aliphatic polyketones with germicide activity Araya-Hermosilla, Esteban Parlanti, Paola Gemmi, Mauro Mattoli, Virgilio Di Pietro, Sebastiano Iacopini, Dalila Granchi, Carlotta Turchi, Barbara Fratini, Filippo Di Bussolo, Valeria Minutolo, Filippo Picchioni, Francesco Pucci, Andrea RSC Adv Chemistry The COVID-19 pandemic has further confirmed to the community that direct contact with contaminated surfaces and objects represents an important source of pathogen spreading among humans. Therefore, it is of paramount importance to design effective germicidal paints to ensure a rapid and potent disinfectant action of surfaces. In this work, we design novel germicide polymeric coatings by inserting quaternary ammonium and sugar groups on the macromolecular backbone, thus respectively endowing the polymer with germicide features and hydrophilicity to interact with the surfaces. An aliphatic polyketone was selected as a starting polymer matrix that was functionalized with primary amine derivatives via the Paal–Knorr reaction. The resulting polymers were deposited on cellulose filter papers and checkboard charts with excellent coating yield and substrate coverage as determined by scanning electron microscopy for cellulose. Remarkably, the substrates coated by the functional polymers bearing quaternary ammonium compounds showed excellent bactericide properties with antibacterial rate of 99% and logarithmic reduction of >3. Notably, the polymers with higher hydrophobicity showed better retention on the substrate after being treated with water at neutral pH. The Royal Society of Chemistry 2022-12-09 /pmc/articles/PMC9732932/ /pubmed/36540247 http://dx.doi.org/10.1039/d2ra06396d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Araya-Hermosilla, Esteban
Parlanti, Paola
Gemmi, Mauro
Mattoli, Virgilio
Di Pietro, Sebastiano
Iacopini, Dalila
Granchi, Carlotta
Turchi, Barbara
Fratini, Filippo
Di Bussolo, Valeria
Minutolo, Filippo
Picchioni, Francesco
Pucci, Andrea
Functionalized aliphatic polyketones with germicide activity
title Functionalized aliphatic polyketones with germicide activity
title_full Functionalized aliphatic polyketones with germicide activity
title_fullStr Functionalized aliphatic polyketones with germicide activity
title_full_unstemmed Functionalized aliphatic polyketones with germicide activity
title_short Functionalized aliphatic polyketones with germicide activity
title_sort functionalized aliphatic polyketones with germicide activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732932/
https://www.ncbi.nlm.nih.gov/pubmed/36540247
http://dx.doi.org/10.1039/d2ra06396d
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