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MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

BACKGROUND: Metabolic reprogramming is a hallmark of cancer, alteration of nucleotide metabolism of hepatocellular carcinoma (HCC) is not well-understood. MYBL2 regulates cell cycle progression and hepatocarcinogenesis, its role in metabolic regulation remains elusive. PATIENTS AND METHODS: Copy num...

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Detalles Bibliográficos
Autores principales:	Zhao, Jun-Zhang, Wang, Wei, Liu, Tao, Zhang, Lei, Lin, De-Zheng, Yao, Jia-Yin, Peng, Xiang, Jin, Gang, Ma, Tian-Tian, Gao, Jin-Bo, Huang, Fang, Nie, Jun, Lv, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733023/ https://www.ncbi.nlm.nih.gov/pubmed/36494680 http://dx.doi.org/10.1186/s12885-022-10354-4

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