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CRAG: de novo characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencing

The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the cell-free DNA fragmentation hotspots from plasma whole-genome sequencing. Hotspots are enriched in open chromatin regions, and, interestingly, 3′end o...

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Detalles Bibliográficos
Autores principales:	Zhou, Xionghui, Zheng, Haizi, Fu, Hailu, Dillehay McKillip, Kelsey L., Pinney, Susan M., Liu, Yaping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733064/ https://www.ncbi.nlm.nih.gov/pubmed/36482487 http://dx.doi.org/10.1186/s13073-022-01141-8

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