Desferrioxamine alleviates UHMWPE particle-induced osteoclastic osteolysis by inhibiting caspase-1-dependent pyroptosis in osteocytes

BACKGROUND: Cell death and inflammation are the two important triggers of wear particle-induced osteolysis. Particles, including cobalt-chromium-molybdenum and tricalcium phosphate, have been reported to induce pyroptosis in macrophages and osteocytes. Although macrophage pyroptosis facilitates oste...

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Detalles Bibliográficos
Autores principales: Zhao, Shenli, Ge, Chen, Li, Yao, Chang, Leilei, Dan, Zhou, Tu, Yihui, Deng, Lianfu, Kang, Hui, Li, Changwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733322/
https://www.ncbi.nlm.nih.gov/pubmed/36482442
http://dx.doi.org/10.1186/s13036-022-00314-8

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