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Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study
BACKGROUND: Allergic status has been strongly influenced by early exposures; however, allergic diseases are hard to measure in early life. Thus, this study proposed a latent variable allergy traits around the second year of life and analyzed pre- and perinatal factors associated with this phenomenon...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733343/ https://www.ncbi.nlm.nih.gov/pubmed/36482361 http://dx.doi.org/10.1186/s12887-022-03772-7 |
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author | Muniz, Alessandra Karla Oliveira Amorim Ribeiro, Cecilia Claudia Costa Vianna, Elcio Oliveira Serra, Hellen Cristina Oliveira Amorim Nascimento, Joelma Ximenes Prado Teixeira Cardoso, Viviane Cunha Barbieri, Marco Antonio da Silva, Antonio Augusto Moura Bettiol, Heloisa |
author_facet | Muniz, Alessandra Karla Oliveira Amorim Ribeiro, Cecilia Claudia Costa Vianna, Elcio Oliveira Serra, Hellen Cristina Oliveira Amorim Nascimento, Joelma Ximenes Prado Teixeira Cardoso, Viviane Cunha Barbieri, Marco Antonio da Silva, Antonio Augusto Moura Bettiol, Heloisa |
author_sort | Muniz, Alessandra Karla Oliveira Amorim |
collection | PubMed |
description | BACKGROUND: Allergic status has been strongly influenced by early exposures; however, allergic diseases are hard to measure in early life. Thus, this study proposed a latent variable allergy traits around the second year of life and analyzed pre- and perinatal factors associated with this phenomenon. METHODS: The study used data from the BRISA birth cohort, Ribeirão Preto, Brazil (n = 3644). The theoretical model included: family allergy (history of allergic rhinitis, atopic dermatitis, and asthma); gestational period variables (socioeconomic status, mother’s skin color, pregestational body mass index – BMI, smoking, gestational diabetes, and hypertension); birth variables (gestational age, 5-minute Apgar score, birth weight, type of delivery), and early life factor (exclusive breast feeding). The outcome was allergy traits around the 2nd year of life, a latent variable deduced from the shared variance among medical diagnosis of allergic rhinitis, atopic dermatitis, and food allergy. The model was analyzed by structural equation modeling. RESULTS: Higher socioeconomic status (SC = 0.256; p < 0.001) and higher family allergy values (SC = 1.224; p < 0.001) were associated with higher allergy trait values. Hypertension during pregnancy was associated with higher values (SC = 0.170; p = 0.022) and exclusive breast feeding (SC = -0.192; p < 0.001) with low allergy trait values. CONCLUSION: Although socioeconomic and environmental factors were associated with allergy traits around the 2nd year of life, the family component of allergy was the exposure that best explained this outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03772-7. |
format | Online Article Text |
id | pubmed-9733343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97333432022-12-10 Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study Muniz, Alessandra Karla Oliveira Amorim Ribeiro, Cecilia Claudia Costa Vianna, Elcio Oliveira Serra, Hellen Cristina Oliveira Amorim Nascimento, Joelma Ximenes Prado Teixeira Cardoso, Viviane Cunha Barbieri, Marco Antonio da Silva, Antonio Augusto Moura Bettiol, Heloisa BMC Pediatr Research BACKGROUND: Allergic status has been strongly influenced by early exposures; however, allergic diseases are hard to measure in early life. Thus, this study proposed a latent variable allergy traits around the second year of life and analyzed pre- and perinatal factors associated with this phenomenon. METHODS: The study used data from the BRISA birth cohort, Ribeirão Preto, Brazil (n = 3644). The theoretical model included: family allergy (history of allergic rhinitis, atopic dermatitis, and asthma); gestational period variables (socioeconomic status, mother’s skin color, pregestational body mass index – BMI, smoking, gestational diabetes, and hypertension); birth variables (gestational age, 5-minute Apgar score, birth weight, type of delivery), and early life factor (exclusive breast feeding). The outcome was allergy traits around the 2nd year of life, a latent variable deduced from the shared variance among medical diagnosis of allergic rhinitis, atopic dermatitis, and food allergy. The model was analyzed by structural equation modeling. RESULTS: Higher socioeconomic status (SC = 0.256; p < 0.001) and higher family allergy values (SC = 1.224; p < 0.001) were associated with higher allergy trait values. Hypertension during pregnancy was associated with higher values (SC = 0.170; p = 0.022) and exclusive breast feeding (SC = -0.192; p < 0.001) with low allergy trait values. CONCLUSION: Although socioeconomic and environmental factors were associated with allergy traits around the 2nd year of life, the family component of allergy was the exposure that best explained this outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03772-7. BioMed Central 2022-12-08 /pmc/articles/PMC9733343/ /pubmed/36482361 http://dx.doi.org/10.1186/s12887-022-03772-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Muniz, Alessandra Karla Oliveira Amorim Ribeiro, Cecilia Claudia Costa Vianna, Elcio Oliveira Serra, Hellen Cristina Oliveira Amorim Nascimento, Joelma Ximenes Prado Teixeira Cardoso, Viviane Cunha Barbieri, Marco Antonio da Silva, Antonio Augusto Moura Bettiol, Heloisa Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title | Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title_full | Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title_fullStr | Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title_full_unstemmed | Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title_short | Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
title_sort | factors associated with allergy traits around the 2nd year of life: a brazilian cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733343/ https://www.ncbi.nlm.nih.gov/pubmed/36482361 http://dx.doi.org/10.1186/s12887-022-03772-7 |
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