The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model

BACKGROUND: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and remains without effective cure. Increasing evidence is supporting the mitochondrial cascade hypothesis, proposing that loss of mitochondrial fitness and subsequent ROS and ATP imbalance are important c...

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Detalles Bibliográficos
Autores principales: de Veij Mestdagh, Christina F., Koopmans, Frank, Breiter, Jonathan C., Timmerman, Jaap A., Vogelaar, Pieter C., Krenning, Guido, Mansvelder, Huibert D., Smit, August B., Henning, Robert H., van Kesteren, Ronald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733344/
https://www.ncbi.nlm.nih.gov/pubmed/36482297
http://dx.doi.org/10.1186/s13195-022-01127-z

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