Cargando…
Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis
Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Opto...
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Publishers
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733677/ https://www.ncbi.nlm.nih.gov/pubmed/36370877 http://dx.doi.org/10.1016/j.jconrel.2022.11.008 |
| _version_ | 1784846426469040128 |
|---|---|
| author | Audouard, Emilie Michel, Fanny Pierroz, Vanessa Kim, Taeuk Rousselot, Lisa Gillet-Legrand, Béatrix Dufayet-Chauffaut, Gaëlle Buchmann, Peter Florea, Michael Khel, Alexander Altynbekova, Kamilya Delgaldo, Claudia Escudero, Encarna Soler, Alejandra Ben Aissa Cartier, Nathalie Piguet, Francoise Folcher, Marc |
| author_facet | Audouard, Emilie Michel, Fanny Pierroz, Vanessa Kim, Taeuk Rousselot, Lisa Gillet-Legrand, Béatrix Dufayet-Chauffaut, Gaëlle Buchmann, Peter Florea, Michael Khel, Alexander Altynbekova, Kamilya Delgaldo, Claudia Escudero, Encarna Soler, Alejandra Ben Aissa Cartier, Nathalie Piguet, Francoise Folcher, Marc |
| author_sort | Audouard, Emilie |
| collection | PubMed |
| description | Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis. |
| format | Online Article Text |
| id | pubmed-9733677 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Science Publishers |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-97336772022-12-12 Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis Audouard, Emilie Michel, Fanny Pierroz, Vanessa Kim, Taeuk Rousselot, Lisa Gillet-Legrand, Béatrix Dufayet-Chauffaut, Gaëlle Buchmann, Peter Florea, Michael Khel, Alexander Altynbekova, Kamilya Delgaldo, Claudia Escudero, Encarna Soler, Alejandra Ben Aissa Cartier, Nathalie Piguet, Francoise Folcher, Marc J Control Release Article Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis. Elsevier Science Publishers 2022-12 /pmc/articles/PMC9733677/ /pubmed/36370877 http://dx.doi.org/10.1016/j.jconrel.2022.11.008 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Audouard, Emilie Michel, Fanny Pierroz, Vanessa Kim, Taeuk Rousselot, Lisa Gillet-Legrand, Béatrix Dufayet-Chauffaut, Gaëlle Buchmann, Peter Florea, Michael Khel, Alexander Altynbekova, Kamilya Delgaldo, Claudia Escudero, Encarna Soler, Alejandra Ben Aissa Cartier, Nathalie Piguet, Francoise Folcher, Marc Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title | Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title_full | Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title_fullStr | Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title_full_unstemmed | Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title_short | Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| title_sort | bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733677/ https://www.ncbi.nlm.nih.gov/pubmed/36370877 http://dx.doi.org/10.1016/j.jconrel.2022.11.008 |
| work_keys_str_mv | AT audouardemilie bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT michelfanny bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT pierrozvanessa bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT kimtaeuk bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT rousselotlisa bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT gilletlegrandbeatrix bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT dufayetchauffautgaelle bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT buchmannpeter bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT floreamichael bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT khelalexander bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT altynbekovakamilya bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT delgaldoclaudia bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT escuderoencarna bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT soleralejandrabenaissa bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT cartiernathalie bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT piguetfrancoise bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis AT folchermarc bioelectroniccellbaseddeviceprovidesastrategyforthetreatmentoftheexperimentalmodelofmultiplesclerosis |