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Combining drug salt formation with amorphous solid dispersions – a double edged sword
Glass transition temperature (T(g)) is important for amorphous compounds because it can have implications on their physical and chemical stability. With drugs that possess ionizable acidic or basic groups, salt formation is a potential strategy to reduce re-crystallization tendency through T(g) elev...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science Publishers
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733678/ https://www.ncbi.nlm.nih.gov/pubmed/36206947 http://dx.doi.org/10.1016/j.jconrel.2022.09.056 |