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Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana

OBJECTIVE. To develop a tool that measures levels of adherence to antiretroviral treatment (ART) in resource-poor settings, based on a combination of four methods for measuring adherence. METHODS. Retrospective review of 500 medical records of people living with HIV, randomly selected from October 2...

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Autores principales: Báez, Pamela, Tiburcio, Adriana, Alba, Nicole, Mateo, Fernando, Grullon, Estefani, Cordero, Sheyla, Fernández, Ana, Reinoso, Janetly, Cruz, Desireé, Gómez, Karina, Vargas, Natacha, Saint-Hilaire, Camila, Abreu, Olga, Acosta, Grace, Halpern, Mina, Stonbraker, Samantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Organización Panamericana de la Salud 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733707/
https://www.ncbi.nlm.nih.gov/pubmed/36519067
http://dx.doi.org/10.26633/RPSP.2022.207
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author Báez, Pamela
Tiburcio, Adriana
Alba, Nicole
Mateo, Fernando
Grullon, Estefani
Cordero, Sheyla
Fernández, Ana
Reinoso, Janetly
Cruz, Desireé
Gómez, Karina
Vargas, Natacha
Saint-Hilaire, Camila
Abreu, Olga
Acosta, Grace
Halpern, Mina
Stonbraker, Samantha
author_facet Báez, Pamela
Tiburcio, Adriana
Alba, Nicole
Mateo, Fernando
Grullon, Estefani
Cordero, Sheyla
Fernández, Ana
Reinoso, Janetly
Cruz, Desireé
Gómez, Karina
Vargas, Natacha
Saint-Hilaire, Camila
Abreu, Olga
Acosta, Grace
Halpern, Mina
Stonbraker, Samantha
author_sort Báez, Pamela
collection PubMed
description OBJECTIVE. To develop a tool that measures levels of adherence to antiretroviral treatment (ART) in resource-poor settings, based on a combination of four methods for measuring adherence. METHODS. Retrospective review of 500 medical records of people living with HIV, randomly selected from October 2017 to January 2020. Adherence to ART was measured by combining four measurement methods (coverage of prescribed ART, ART picked up at pharmacies, viral load, and self-reported adherence). Chi-squared tests were performed with p<0.05 for statistically significant differences and logistic binary regression to identify the probability of optimal and suboptimal adherence. Spearman tests were performed for correlation of categories, and Cronbach’s alpha was used to measure the internal consistency of the tool. RESULTS. We obtained 497 adherence scores. Of these, 307 (61.8%) users qualified as adherent, 141 (28.4%) as semi-adherent, and 49 (9.8%) as non-adherent. A higher probability of optimal adherence was found in groups aged 60 years and older (odds ratio [OR]: 1.6; CI95%: 0.8–3.5), with no difference between men and women (OR: 0.9; CI95%: 0.7–1.4). Spearman’s test reported a relationship (r = 0.8) between viral load levels and final score, and Cronbach’s alpha yielded modest internal consistency (α = 0.7). CONCLUSIONS. A tool was developed to measure adherence to ART in a resource-poor environment. The tool shows modest levels of internal consistency and a strong correlation between viral load and adherence.
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spelling pubmed-97337072022-12-13 Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana Báez, Pamela Tiburcio, Adriana Alba, Nicole Mateo, Fernando Grullon, Estefani Cordero, Sheyla Fernández, Ana Reinoso, Janetly Cruz, Desireé Gómez, Karina Vargas, Natacha Saint-Hilaire, Camila Abreu, Olga Acosta, Grace Halpern, Mina Stonbraker, Samantha Rev Panam Salud Publica Investigación Original OBJECTIVE. To develop a tool that measures levels of adherence to antiretroviral treatment (ART) in resource-poor settings, based on a combination of four methods for measuring adherence. METHODS. Retrospective review of 500 medical records of people living with HIV, randomly selected from October 2017 to January 2020. Adherence to ART was measured by combining four measurement methods (coverage of prescribed ART, ART picked up at pharmacies, viral load, and self-reported adherence). Chi-squared tests were performed with p<0.05 for statistically significant differences and logistic binary regression to identify the probability of optimal and suboptimal adherence. Spearman tests were performed for correlation of categories, and Cronbach’s alpha was used to measure the internal consistency of the tool. RESULTS. We obtained 497 adherence scores. Of these, 307 (61.8%) users qualified as adherent, 141 (28.4%) as semi-adherent, and 49 (9.8%) as non-adherent. A higher probability of optimal adherence was found in groups aged 60 years and older (odds ratio [OR]: 1.6; CI95%: 0.8–3.5), with no difference between men and women (OR: 0.9; CI95%: 0.7–1.4). Spearman’s test reported a relationship (r = 0.8) between viral load levels and final score, and Cronbach’s alpha yielded modest internal consistency (α = 0.7). CONCLUSIONS. A tool was developed to measure adherence to ART in a resource-poor environment. The tool shows modest levels of internal consistency and a strong correlation between viral load and adherence. Organización Panamericana de la Salud 2022-12-09 /pmc/articles/PMC9733707/ /pubmed/36519067 http://dx.doi.org/10.26633/RPSP.2022.207 Text en https://creativecommons.org/licenses/by/4.0/Este es un artículo de acceso abierto distribuido según lo establecido en la licencia Creative Commons (CC BY 4.0) de reconocimiento, que permite a otros distribuir, combinar, adaptar y aprovechar esta obra con fines comerciales, siempre que se cite la obra original de la manera apropiada. Véase: http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) Crédito del logo y el texto open access: PLoS, bajo licencia Creative Commons Attribution-Share Alike 3.0 Unported.
spellingShingle Investigación Original
Báez, Pamela
Tiburcio, Adriana
Alba, Nicole
Mateo, Fernando
Grullon, Estefani
Cordero, Sheyla
Fernández, Ana
Reinoso, Janetly
Cruz, Desireé
Gómez, Karina
Vargas, Natacha
Saint-Hilaire, Camila
Abreu, Olga
Acosta, Grace
Halpern, Mina
Stonbraker, Samantha
Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title_full Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title_fullStr Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title_full_unstemmed Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title_short Medición de adherencia a antirretrovirales con métodos múltiples en La Romana, República Dominicana
title_sort medición de adherencia a antirretrovirales con métodos múltiples en la romana, república dominicana
topic Investigación Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733707/
https://www.ncbi.nlm.nih.gov/pubmed/36519067
http://dx.doi.org/10.26633/RPSP.2022.207
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