Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy

Remdesivir is an antiviral agent used as supportive care in adults with SARS-COV2-induced pneumonia. We report a case of an 81-year-old patient who developed hepatocellular acute liver injury 48 hours after initiating remdesivir. During the investigation, other causes of hepatotoxicity were excluded...

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Autores principales: Dividis, Georgios P, Papadopoulos, Georgios E, Karageorgiou, Ioannis, Kotronis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733800/
https://www.ncbi.nlm.nih.gov/pubmed/36514704
http://dx.doi.org/10.7759/cureus.32353
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author Dividis, Georgios P
Papadopoulos, Georgios E
Karageorgiou, Ioannis
Kotronis, Georgios
author_facet Dividis, Georgios P
Papadopoulos, Georgios E
Karageorgiou, Ioannis
Kotronis, Georgios
author_sort Dividis, Georgios P
collection PubMed
description Remdesivir is an antiviral agent used as supportive care in adults with SARS-COV2-induced pneumonia. We report a case of an 81-year-old patient who developed hepatocellular acute liver injury 48 hours after initiating remdesivir. During the investigation, other causes of hepatotoxicity were excluded. A decrease in transaminases and international normalized ratio (INR) was observed 24 hours after cessation of remdesivir. An abdominal CT demonstrated hepatic congestion, retrograde hepatic venous opacification shortly after intravenous contrast injection, and dilatation of hepatic veins and inferior vena cava. We suggest congestive hepatopathy secondary to remdesivir as a possible component of liver injury.
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spelling pubmed-97338002022-12-12 Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy Dividis, Georgios P Papadopoulos, Georgios E Karageorgiou, Ioannis Kotronis, Georgios Cureus Internal Medicine Remdesivir is an antiviral agent used as supportive care in adults with SARS-COV2-induced pneumonia. We report a case of an 81-year-old patient who developed hepatocellular acute liver injury 48 hours after initiating remdesivir. During the investigation, other causes of hepatotoxicity were excluded. A decrease in transaminases and international normalized ratio (INR) was observed 24 hours after cessation of remdesivir. An abdominal CT demonstrated hepatic congestion, retrograde hepatic venous opacification shortly after intravenous contrast injection, and dilatation of hepatic veins and inferior vena cava. We suggest congestive hepatopathy secondary to remdesivir as a possible component of liver injury. Cureus 2022-12-09 /pmc/articles/PMC9733800/ /pubmed/36514704 http://dx.doi.org/10.7759/cureus.32353 Text en Copyright © 2022, Dividis et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Dividis, Georgios P
Papadopoulos, Georgios E
Karageorgiou, Ioannis
Kotronis, Georgios
Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title_full Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title_fullStr Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title_full_unstemmed Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title_short Remdesivir-Induced Liver Injury in a Patient With Coronavirus Disease 2019 and History of Congestive Hepatopathy
title_sort remdesivir-induced liver injury in a patient with coronavirus disease 2019 and history of congestive hepatopathy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733800/
https://www.ncbi.nlm.nih.gov/pubmed/36514704
http://dx.doi.org/10.7759/cureus.32353
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