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Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism

Objective: The aim of this study was to establish a population pharmacokinetic (PPK) model of valproic acid (VPA) in pediatric patients with epilepsy in southern China, and provide guidance for individualized medication of VPA therapy. Methods: A total of 376 VPA steady-state trough concentrations w...

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Detalles Bibliográficos
Autores principales:	Shen, Xianhuan, Chen, Xinyi, Lu, Jieluan, Chen, Qing, Li, Wenzhou, Zhu, Jiahao, He, Yaodong, Guo, Huijuan, Xu, Chenshu, Fan, Xiaomei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733833/ https://www.ncbi.nlm.nih.gov/pubmed/36506519 http://dx.doi.org/10.3389/fphar.2022.1037239

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