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Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea

There is yet to be a large-scale longitudinal study on the course of depression incidence within the duration of cirrhosis. The aim of this study is to analyze the incidence of depression from before to after diagnosis of cirrhosis over time. Incidence Rate (IR) was defined as the number of newly di...

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Autores principales: Seo, Gi Hyeon, Yoo, Jeong-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733842/
https://www.ncbi.nlm.nih.gov/pubmed/36490257
http://dx.doi.org/10.1371/journal.pone.0278924
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author Seo, Gi Hyeon
Yoo, Jeong-Ju
author_facet Seo, Gi Hyeon
Yoo, Jeong-Ju
author_sort Seo, Gi Hyeon
collection PubMed
description There is yet to be a large-scale longitudinal study on the course of depression incidence within the duration of cirrhosis. The aim of this study is to analyze the incidence of depression from before to after diagnosis of cirrhosis over time. Incidence Rate (IR) was defined as the number of newly diagnosed patients with MDD divided by the sum of observation periods by using claims database in Korea. Incidence Rate Ratio (IRR) was defined as the IR in the specific interest period divided by the IR in the control period. The control period was defied as 1 to 2 years before diagnosis of cirrhosis. The IRs before and after cirrhosis diagnosis were 3.56 and 7.54 per 100 person-year, respectively. The IRR was 2.12 (95% confidence Interval: 2.06–2.18). The IRR of developing depression mildly increased before diagnosis of cirrhosis (-360 days to -181 days, IRR 1.14, p < 0.001; -180 days to -90 days, IRR 1.24, p < 0.001; -90 days to -31 days, IRR 1.56, p < 0.001) and rapidly increased immediately after diagnosis of cirrhosis (+30 days to +89 days, IRR 2.12, 95% confidence interval: 2.06–2.18, p < 0.001). The pattern of increasing depression immediately after the diagnosis of cirrhosis was observed equally in all sexes and ages. Thus, clinicians must pay close attention to screening for depression within the first three months of liver cirrhosis diagnosis.
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spelling pubmed-97338422022-12-10 Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea Seo, Gi Hyeon Yoo, Jeong-Ju PLoS One Research Article There is yet to be a large-scale longitudinal study on the course of depression incidence within the duration of cirrhosis. The aim of this study is to analyze the incidence of depression from before to after diagnosis of cirrhosis over time. Incidence Rate (IR) was defined as the number of newly diagnosed patients with MDD divided by the sum of observation periods by using claims database in Korea. Incidence Rate Ratio (IRR) was defined as the IR in the specific interest period divided by the IR in the control period. The control period was defied as 1 to 2 years before diagnosis of cirrhosis. The IRs before and after cirrhosis diagnosis were 3.56 and 7.54 per 100 person-year, respectively. The IRR was 2.12 (95% confidence Interval: 2.06–2.18). The IRR of developing depression mildly increased before diagnosis of cirrhosis (-360 days to -181 days, IRR 1.14, p < 0.001; -180 days to -90 days, IRR 1.24, p < 0.001; -90 days to -31 days, IRR 1.56, p < 0.001) and rapidly increased immediately after diagnosis of cirrhosis (+30 days to +89 days, IRR 2.12, 95% confidence interval: 2.06–2.18, p < 0.001). The pattern of increasing depression immediately after the diagnosis of cirrhosis was observed equally in all sexes and ages. Thus, clinicians must pay close attention to screening for depression within the first three months of liver cirrhosis diagnosis. Public Library of Science 2022-12-09 /pmc/articles/PMC9733842/ /pubmed/36490257 http://dx.doi.org/10.1371/journal.pone.0278924 Text en © 2022 Seo, Yoo https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Seo, Gi Hyeon
Yoo, Jeong-Ju
Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title_full Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title_fullStr Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title_full_unstemmed Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title_short Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea
title_sort incidence of major depressive disorder over time in patients with liver cirrhosis: a nationwide population-based study in korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733842/
https://www.ncbi.nlm.nih.gov/pubmed/36490257
http://dx.doi.org/10.1371/journal.pone.0278924
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