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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy...

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Detalles Bibliográficos
Autores principales:	Meroni, Alice, Grosser, Jan, Agashe, Sumedha, Ramakrishnan, Natasha, Jackson, Jessica, Verma, Priyanka, Baranello, Laura, Vindigni, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733930/ https://www.ncbi.nlm.nih.gov/pubmed/36490343 http://dx.doi.org/10.1126/sciadv.abq0648

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