Cargando…

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro). Polyprotein processing is essential yet incompletely understood. We studied Mpro-mediate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yadav, Ruchi, Courouble, Valentine V., Dey, Sanjay K., Harrison, Jerry Joe E. K., Timm, Jennifer, Hopkins, Jesse B., Slack, Ryan L., Sarafianos, Stefan G., Ruiz, Francesc X., Griffin, Patrick R., Arnold, Eddy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733933/ https://www.ncbi.nlm.nih.gov/pubmed/36490335 http://dx.doi.org/10.1126/sciadv.add2191

Ejemplares similares

Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation
por: Harrison, Jerry Joe E. K., et al.
Publicado: (2022)

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics
por: Courouble, Valentine V., et al.
Publicado: (2021)

Structural and biochemical characteristics of mRNA nanoparticles determine anti–SARS-CoV-2 humoral and cellular immune responses
por: Shi, Yingying, et al.
Publicado: (2022)

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
por: Harrison, Jerry Joe E. K., et al.
Publicado: (2021)

A limit on the evolutionary rescue of an Antarctic bacterium from rising temperatures
por: Toll-Riera, Macarena, et al.
Publicado: (2022)

The structure of a polyketide synthase bimodule core
por: Tittes, Yves U., et al.
Publicado: (2022)

Coupling of protein condensates to ordered lipid domains determines functional membrane organization
por: Wang, Hong-Yin, et al.
Publicado: (2023)

mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs
por: Bartsch, Deniz, et al.
Publicado: (2023)

Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy
por: Wong, Ho Yi, et al.
Publicado: (2023)

Mapping the in vivo fitness landscape of a tethered ribosome
por: Radford, Felix, et al.
Publicado: (2023)

Molecular architecture of the autoinhibited kinesin-1 lambda particle
por: Weijman, Johannes F., et al.
Publicado: (2022)

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice
por: Beckerman, Margarita, et al.
Publicado: (2021)

Design of a minimal di-nickel hydrogenase peptide
por: Timm, Jennifer, et al.
Publicado: (2023)

Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney
por: Pace, Jesse A., et al.
Publicado: (2021)

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
por: Grosskopf, Abigail K., et al.
Publicado: (2022)

Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice
por: Schwarz, Madeline M., et al.
Publicado: (2023)

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities
por: Spetz, Johan K. E., et al.
Publicado: (2022)

Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
por: Liu, Liu, et al.
Publicado: (2022)

Plasma iron controls neutrophil production and function
por: Frost, Joe N., et al.
Publicado: (2022)

Novel suction-based in vivo cutaneous DNA transfection platform
por: Lallow, Emran O., et al.
Publicado: (2021)

NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
por: Anandhan, Annadurai, et al.
Publicado: (2023)

Biphasic control of cell expansion by auxin coordinates etiolated seedling development
por: Du, Minmin, et al.
Publicado: (2022)

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
por: Toelzer, Christine, et al.
Publicado: (2022)

Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
por: Clayton, Sally A., et al.
Publicado: (2021)

Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency
por: Son, Joe Eun, et al.
Publicado: (2021)

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis
por: Kenney, Adam D., et al.
Publicado: (2022)

The ion transporter Na(+)-K(+)-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
por: Chernova, Irene, et al.
Publicado: (2023)

ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer
por: Zhou, Yuzhen, et al.
Publicado: (2023)

Genetically engineered transfusable platelets using mRNA lipid nanoparticles
por: Leung, Jerry, et al.
Publicado: (2023)

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
por: Shindyapina, Anastasia V., et al.
Publicado: (2022)

Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
por: Lee, Wen Shi, et al.
Publicado: (2023)

Ryanodine receptor leak triggers fiber Ca(2+) redistribution to preserve force and elevate basal metabolism in skeletal muscle
por: Lamboley, Cedric R., et al.
Publicado: (2021)

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
por: Herb, Brian R., et al.
Publicado: (2023)

Therapeutic KRAS(G12C) inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers
por: Mugarza, Edurne, et al.
Publicado: (2022)

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques
por: Bewley, Kevin R., et al.
Publicado: (2021)

Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response
por: Wang, Yifei, et al.
Publicado: (2022)

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
por: Coulis, Gerald, et al.
Publicado: (2023)

Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath
por: Ren, Xingjie, et al.
Publicado: (2021)

Structural basis for sarcolipin’s regulation of muscle thermogenesis by the sarcoplasmic reticulum Ca(2+)-ATPase
por: Wang, Songlin, et al.
Publicado: (2021)

Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria
por: Zeldin, Jordan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jt0rutuqepjuvvae4tejjtuluu