Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions rapidly activate the p38 mitogen activated protein kinase (MAPK) pathway, and SARS-CoV-2 spike proteins rapidly activate both the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kyriakopoulos, Anthony M, Nigh, Greg, McCullough, Peter A, Seneff, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733976/
https://www.ncbi.nlm.nih.gov/pubmed/36514706
http://dx.doi.org/10.7759/cureus.32361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733976/
https://www.ncbi.nlm.nih.gov/pubmed/36514706
http://dx.doi.org/10.7759/cureus.32361

Ejemplares similares