Cargando…

Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions rapidly activate the p38 mitogen activated protein kinase (MAPK) pathway, and SARS-CoV-2 spike proteins rapidly activate both the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kyriakopoulos, Anthony M, Nigh, Greg, McCullough, Peter A, Seneff, Stephanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cureus 2022
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733976/ https://www.ncbi.nlm.nih.gov/pubmed/36514706 http://dx.doi.org/10.7759/cureus.32361

Ejemplares similares

A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review
por: Seneff, Stephanie, et al.
Publicado: (2023)

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs
por: Seneff, Stephanie, et al.
Publicado: (2022)

Response to Barriere et al.
por: Seneff, Stephanie, et al.
Publicado: (2023)

Bell’s palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature
por: Kyriakopoulos, Anthony M., et al.
Publicado: (2023)

Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer
por: Donohoe, Fionán, et al.
Publicado: (2020)

Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link
por: Chen, Chaobo, et al.
Publicado: (2019)

The Mitogen-Activated Protein Kinase PlMAPK2 Is Involved in Zoosporogenesis and Pathogenicity of Peronophythora litchii
por: Huang, Jiamin, et al.
Publicado: (2021)

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum
por: Blackwood, Christopher A., et al.
Publicado: (2021)

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids
por: Soares-Silva, Mercedes, et al.
Publicado: (2016)

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers
por: Ahmad, Dena A. J., et al.
Publicado: (2016)

Identification and Analysis of Mitogen-Activated Protein Kinase (MAPK) Cascades in Fragaria vesca
por: Zhou, Heying, et al.
Publicado: (2017)

Role of Trichoderma reesei mitogen-activated protein kinases (MAPKs) in cellulase formation
por: Wang, Mingyu, et al.
Publicado: (2017)

Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i)
por: Ganguly, Payal, et al.
Publicado: (2023)

Mitogen activated protein kinases (MAPK) and protein phosphatases are involved in Aspergillus fumigatus adhesion and biofilm formation
por: Manfiolli, Adriana Oliveira, et al.
Publicado: (2018)

Identification, Nomenclature, and Evolutionary Relationships of Mitogen-Activated Protein Kinase (MAPK) Genes in Soybean
por: Neupane, Achal, et al.
Publicado: (2013)

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks
por: Pan, Lixia, et al.
Publicado: (2020)

Mitogen-Activated Protein Kinases (MAPKs) and Enteric Bacterial Pathogens: A Complex Interplay
por: Nandi, Ipsita, et al.
Publicado: (2023)

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
por: Son, Yong, et al.
Publicado: (2011)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

EhMAPK, the Mitogen-Activated Protein Kinase from Entamoeba histolytica Is Associated with Cell Survival
por: Sardar Ghosh, Anupama, et al.
Publicado: (2010)

Characterization of mitogen activated protein kinases (MAPKs) in the Curcuma longa expressed sequence tag database
por: Joshi, Raj Kumar, et al.
Publicado: (2011)

Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion
por: Ihermann-Hella, Anneliis, et al.
Publicado: (2014)

Identification and Characterization of Mitogen-Activated Protein Kinase (MAPK) Genes in Sunflower (Helianthus annuus L.)
por: Neupane, Surendra, et al.
Publicado: (2019)

New aspects of p38 mitogen activated protein kinase (MAPK) biology in lung inflammation
por: Newton, Robert, et al.
Publicado: (2006)

ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling
por: Arya, Subhash B., et al.
Publicado: (2018)

p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle
por: Evertsson, Kim, et al.
Publicado: (2014)

The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo
por: Xiong, Cong, et al.
Publicado: (2015)

Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity
por: Gu, Yue, et al.
Publicado: (2018)

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis
por: Uimari, Outi, et al.
Publicado: (2017)

PlMAPK10, a Mitogen-Activated Protein Kinase (MAPK) in Peronophythora litchii, Is Required for Mycelial Growth, Sporulation, Laccase Activity, and Plant Infection
por: Jiang, Liqun, et al.
Publicado: (2018)

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations
por: Boru, Getachew, et al.
Publicado: (2019)

Editorial: Mitogen Activated Protein Kinases
por: Cuenda, Ana, et al.
Publicado: (2017)

Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes
por: Li, Yanzhang, et al.
Publicado: (2022)

Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis
por: Huynh, Hung, et al.
Publicado: (2003)

Genome-wide identification of mitogen-activated protein kinase (MAPK) cascade and expression profiling of CmMAPKs in melon (Cucumis melo L.)
por: Zhang, Xiaolan, et al.
Publicado: (2020)

Cold Physical Plasma Modulates p53 and Mitogen-Activated Protein Kinase Signaling in Keratinocytes
por: Schmidt, Anke, et al.
Publicado: (2019)

Cefepime-Induced Neurotoxicity
por: Saini, Tanjot, et al.
Publicado: (2021)

Silencing of the Mitogen-Activated Protein Kinases (MAPK) Fus3 and Slt2 in Pseudocercospora fijiensis Reduces Growth and Virulence on Host Plants
por: Onyilo, Francis, et al.
Publicado: (2018)

Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
por: Miura, Kouichi, et al.
Publicado: (2019)

Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei
por: D’Elia, R. V., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s8v10jmrii3ufn6p0aplf5h0re