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Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report
Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown in epidemiological studies to be associated with an increased risk of stillbirth. Several histopathologic features of placental SARS-CoV-2 infection have been proposed as potential causes of fetal death. W...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733999/ https://www.ncbi.nlm.nih.gov/pubmed/36506700 http://dx.doi.org/10.1155/2022/5404952 |
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author | Gjakov, Boban Kopač, Darja Vukmanič Pohar, Mateja Lučovnik, Miha |
author_facet | Gjakov, Boban Kopač, Darja Vukmanič Pohar, Mateja Lučovnik, Miha |
author_sort | Gjakov, Boban |
collection | PubMed |
description | Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown in epidemiological studies to be associated with an increased risk of stillbirth. Several histopathologic features of placental SARS-CoV-2 infection have been proposed as potential causes of fetal death. We present a case of an otherwise healthy G3P1 women with mild symptoms of SARS-CoV-2 infection at 23 6/7 weeks of gestation. At 25 2/7 weeks, she presented with signs and symptoms of preterm labor and decreased fetal movements. Fetal death was diagnosed at admission. Placental pathology showed pronounced placental mixed intervillositis. Inflammatory infiltrate caused extreme narrowing of intervillous space leading to placental malfunction and fetal death. Placental tissue SARS-CoV-2 infection was confirmed by positive immunohistochemistry staining of syncytiotrophoblasts with spike protein antibody. The case presented suggests that SARS-CoV-2 associated inflammatory placental changes pose an elevated risk for the fetus. |
format | Online Article Text |
id | pubmed-9733999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-97339992022-12-10 Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report Gjakov, Boban Kopač, Darja Vukmanič Pohar, Mateja Lučovnik, Miha Case Rep Obstet Gynecol Case Report Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown in epidemiological studies to be associated with an increased risk of stillbirth. Several histopathologic features of placental SARS-CoV-2 infection have been proposed as potential causes of fetal death. We present a case of an otherwise healthy G3P1 women with mild symptoms of SARS-CoV-2 infection at 23 6/7 weeks of gestation. At 25 2/7 weeks, she presented with signs and symptoms of preterm labor and decreased fetal movements. Fetal death was diagnosed at admission. Placental pathology showed pronounced placental mixed intervillositis. Inflammatory infiltrate caused extreme narrowing of intervillous space leading to placental malfunction and fetal death. Placental tissue SARS-CoV-2 infection was confirmed by positive immunohistochemistry staining of syncytiotrophoblasts with spike protein antibody. The case presented suggests that SARS-CoV-2 associated inflammatory placental changes pose an elevated risk for the fetus. Hindawi 2022-12-02 /pmc/articles/PMC9733999/ /pubmed/36506700 http://dx.doi.org/10.1155/2022/5404952 Text en Copyright © 2022 Boban Gjakov et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Gjakov, Boban Kopač, Darja Vukmanič Pohar, Mateja Lučovnik, Miha Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title | Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title_full | Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title_fullStr | Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title_full_unstemmed | Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title_short | Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report |
title_sort | mixed intervillositis in sars-cov-2 infection associated with fetal death: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733999/ https://www.ncbi.nlm.nih.gov/pubmed/36506700 http://dx.doi.org/10.1155/2022/5404952 |
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