Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental and biological factors. Paradoxically, clinical studies suggest an attenuation of APOE ε4 risk of dementia in African ancestry (AFR), but a dearth of neuropathological data preclude the interpretation o...

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Detalles Bibliográficos
Autores principales: Naslavsky, Michel Satya, Suemoto, Claudia K., Brito, Luciano Abreu, Scliar, Marília Oliveira, Ferretti-Rebustini, Renata Eloah, Rodriguez, Roberta Diehl, Leite, Renata E. P., Araujo, Nathalia Matta, Borda, Victor, Tarazona-Santos, Eduardo, Jacob-Filho, Wilson, Pasqualucci, Carlos, Nitrini, Ricardo, Yaffe, Kristine, Zatz, Mayana, Grinberg, Lea T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734036/
https://www.ncbi.nlm.nih.gov/pubmed/36071110
http://dx.doi.org/10.1038/s41380-022-01729-x

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