High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens

Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder and depressive phenotypes in mice. Initially, we identified an enhanced glutamatergic input i...

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Detalles Bibliográficos
Autores principales: Tsai, Sheng-Feng, Hsu, Pei-Ling, Chen, Yun-Wen, Hossain, Mohammad Shahadat, Chen, Pei-Chun, Tzeng, Shun-Fen, Chen, Po-See, Kuo, Yu-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734059/
https://www.ncbi.nlm.nih.gov/pubmed/36180573
http://dx.doi.org/10.1038/s41380-022-01787-1

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