Selective posttranslational inhibition of Ca(V)β(1)-associated voltage-dependent calcium channels with a functionalized nanobody

Ca(2+) influx through high-voltage-activated calcium channels (HVACCs) controls diverse cellular functions. A critical feature enabling a singular signal, Ca(2+) influx, to mediate disparate functions is diversity of HVACC pore-forming α(1) and auxiliary Ca(V)β(1)–Ca(V)β(4) subunits. Selective Ca(V)...

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Detalles Bibliográficos
Autores principales: Morgenstern, Travis J., Nirwan, Neha, Hernández-Ochoa, Erick O., Bibollet, Hugo, Choudhury, Papiya, Laloudakis, Yianni D., Ben Johny, Manu, Bannister, Roger A., Schneider, Martin F., Minor, Daniel L., Colecraft, Henry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734117/
https://www.ncbi.nlm.nih.gov/pubmed/36494348
http://dx.doi.org/10.1038/s41467-022-35025-7

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