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Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic le...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734119/ https://www.ncbi.nlm.nih.gov/pubmed/36494491 http://dx.doi.org/10.1038/s41598-022-25634-z |
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author | Krishnan, Prakash Sharma, Raman Avadhani, Sriya Tarricone, Arthur Gee, Allen Farhan, Serdar Kamran, Haroon Kini, Annapoorna Sharma, Samin |
author_facet | Krishnan, Prakash Sharma, Raman Avadhani, Sriya Tarricone, Arthur Gee, Allen Farhan, Serdar Kamran, Haroon Kini, Annapoorna Sharma, Samin |
author_sort | Krishnan, Prakash |
collection | PubMed |
description | Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic lesions. However, the clinical effects of vessel preparation with DCB in nominal, compressed, and elongated Supera has not been widely studied. The purpose of this study is to assess the outcomes of clinically driven re-intervention, major amputations, and mortality in relation to the use of DCB as vessel preparation in different deployment conditions (nominal, compressed, elongated) of the Supera stent. Patient chart data was collected at a single center hospital between March 2015 and May 2020. All patients were adults (≥ 18 years old) and were treated with at least one (≥ 1) Supera stent. Deployment status was extrapolated from anonymized angiograms. The primary endpoint of this study was CD-TLR. Secondary endpoints included amputation and mortality rates associated with each deployment condition. A total of 670 limbs were treated and patients were followed for 36 months. Nominal stent deployment was observed in 337 limbs, followed by elongated condition (n = 176), then by compressed conditions (n = 159). CD-TLR was observed most frequently with elongated deployment. Drug coated balloons were used as vessel prep prior to stenting and showed a protective effect regardless of deployment status; O.R = 0.44 (CI 0.30–0.66, p < .05). |
format | Online Article Text |
id | pubmed-9734119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97341192022-12-11 Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term Krishnan, Prakash Sharma, Raman Avadhani, Sriya Tarricone, Arthur Gee, Allen Farhan, Serdar Kamran, Haroon Kini, Annapoorna Sharma, Samin Sci Rep Article Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic lesions. However, the clinical effects of vessel preparation with DCB in nominal, compressed, and elongated Supera has not been widely studied. The purpose of this study is to assess the outcomes of clinically driven re-intervention, major amputations, and mortality in relation to the use of DCB as vessel preparation in different deployment conditions (nominal, compressed, elongated) of the Supera stent. Patient chart data was collected at a single center hospital between March 2015 and May 2020. All patients were adults (≥ 18 years old) and were treated with at least one (≥ 1) Supera stent. Deployment status was extrapolated from anonymized angiograms. The primary endpoint of this study was CD-TLR. Secondary endpoints included amputation and mortality rates associated with each deployment condition. A total of 670 limbs were treated and patients were followed for 36 months. Nominal stent deployment was observed in 337 limbs, followed by elongated condition (n = 176), then by compressed conditions (n = 159). CD-TLR was observed most frequently with elongated deployment. Drug coated balloons were used as vessel prep prior to stenting and showed a protective effect regardless of deployment status; O.R = 0.44 (CI 0.30–0.66, p < .05). Nature Publishing Group UK 2022-12-09 /pmc/articles/PMC9734119/ /pubmed/36494491 http://dx.doi.org/10.1038/s41598-022-25634-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Krishnan, Prakash Sharma, Raman Avadhani, Sriya Tarricone, Arthur Gee, Allen Farhan, Serdar Kamran, Haroon Kini, Annapoorna Sharma, Samin Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title | Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title_full | Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title_fullStr | Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title_full_unstemmed | Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title_short | Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term |
title_sort | drug coated balloon improves outcomes of sub-optimal supera deployment in the intermediate term |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734119/ https://www.ncbi.nlm.nih.gov/pubmed/36494491 http://dx.doi.org/10.1038/s41598-022-25634-z |
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