Cargando…

Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term

Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic le...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishnan, Prakash, Sharma, Raman, Avadhani, Sriya, Tarricone, Arthur, Gee, Allen, Farhan, Serdar, Kamran, Haroon, Kini, Annapoorna, Sharma, Samin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734119/
https://www.ncbi.nlm.nih.gov/pubmed/36494491
http://dx.doi.org/10.1038/s41598-022-25634-z
_version_ 1784846518958686208
author Krishnan, Prakash
Sharma, Raman
Avadhani, Sriya
Tarricone, Arthur
Gee, Allen
Farhan, Serdar
Kamran, Haroon
Kini, Annapoorna
Sharma, Samin
author_facet Krishnan, Prakash
Sharma, Raman
Avadhani, Sriya
Tarricone, Arthur
Gee, Allen
Farhan, Serdar
Kamran, Haroon
Kini, Annapoorna
Sharma, Samin
author_sort Krishnan, Prakash
collection PubMed
description Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic lesions. However, the clinical effects of vessel preparation with DCB in nominal, compressed, and elongated Supera has not been widely studied. The purpose of this study is to assess the outcomes of clinically driven re-intervention, major amputations, and mortality in relation to the use of DCB as vessel preparation in different deployment conditions (nominal, compressed, elongated) of the Supera stent. Patient chart data was collected at a single center hospital between March 2015 and May 2020. All patients were adults (≥ 18 years old) and were treated with at least one (≥ 1) Supera stent. Deployment status was extrapolated from anonymized angiograms. The primary endpoint of this study was CD-TLR. Secondary endpoints included amputation and mortality rates associated with each deployment condition. A total of 670 limbs were treated and patients were followed for 36 months. Nominal stent deployment was observed in 337 limbs, followed by elongated condition (n = 176), then by compressed conditions (n = 159). CD-TLR was observed most frequently with elongated deployment. Drug coated balloons were used as vessel prep prior to stenting and showed a protective effect regardless of deployment status; O.R = 0.44 (CI 0.30–0.66, p < .05).
format Online
Article
Text
id pubmed-9734119
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-97341192022-12-11 Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term Krishnan, Prakash Sharma, Raman Avadhani, Sriya Tarricone, Arthur Gee, Allen Farhan, Serdar Kamran, Haroon Kini, Annapoorna Sharma, Samin Sci Rep Article Sub-Optimal deployment of Self expanding interwoven stents (Supera) has been shown to increase the rate of Clinically Driven Target Lesion Revascularization (CD-TLR). Meanwhile, drug coated balloons (DCB) have been shown to reduce CD-TLR in the femoral-popliteal segment in de- novo and restenotic lesions. However, the clinical effects of vessel preparation with DCB in nominal, compressed, and elongated Supera has not been widely studied. The purpose of this study is to assess the outcomes of clinically driven re-intervention, major amputations, and mortality in relation to the use of DCB as vessel preparation in different deployment conditions (nominal, compressed, elongated) of the Supera stent. Patient chart data was collected at a single center hospital between March 2015 and May 2020. All patients were adults (≥ 18 years old) and were treated with at least one (≥ 1) Supera stent. Deployment status was extrapolated from anonymized angiograms. The primary endpoint of this study was CD-TLR. Secondary endpoints included amputation and mortality rates associated with each deployment condition. A total of 670 limbs were treated and patients were followed for 36 months. Nominal stent deployment was observed in 337 limbs, followed by elongated condition (n = 176), then by compressed conditions (n = 159). CD-TLR was observed most frequently with elongated deployment. Drug coated balloons were used as vessel prep prior to stenting and showed a protective effect regardless of deployment status; O.R = 0.44 (CI 0.30–0.66, p < .05). Nature Publishing Group UK 2022-12-09 /pmc/articles/PMC9734119/ /pubmed/36494491 http://dx.doi.org/10.1038/s41598-022-25634-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Krishnan, Prakash
Sharma, Raman
Avadhani, Sriya
Tarricone, Arthur
Gee, Allen
Farhan, Serdar
Kamran, Haroon
Kini, Annapoorna
Sharma, Samin
Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title_full Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title_fullStr Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title_full_unstemmed Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title_short Drug coated balloon improves outcomes of sub-optimal Supera deployment in the intermediate term
title_sort drug coated balloon improves outcomes of sub-optimal supera deployment in the intermediate term
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734119/
https://www.ncbi.nlm.nih.gov/pubmed/36494491
http://dx.doi.org/10.1038/s41598-022-25634-z
work_keys_str_mv AT krishnanprakash drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT sharmaraman drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT avadhanisriya drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT tarriconearthur drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT geeallen drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT farhanserdar drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT kamranharoon drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT kiniannapoorna drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm
AT sharmasamin drugcoatedballoonimprovesoutcomesofsuboptimalsuperadeploymentintheintermediateterm