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COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734167/ https://www.ncbi.nlm.nih.gov/pubmed/36494338 http://dx.doi.org/10.1038/s41421-022-00496-x |
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author | Liang, Hong Nian, Xuanxuan Wu, Junzheng Liu, Dong Feng, Lu Lu, Jia Peng, Yan Zhou, Zhijun Deng, Tao Liu, Jing Ji, Deming Qiu, Ran Lin, Lianzhen Zeng, Yan Xia, Fei Hu, Yong Li, Taojing Duan, Kai Li, Xinguo Wang, Zejun Zhang, Yong Zhang, Hang Zhu, Chen Wang, Shang Wu, Xiao Wang, Xiang Li, Yuwei Huang, Shihe Mao, Min Guo, Huanhuan Yang, Yunkai Jia, Rui Xufang, Jingwei Wang, Xuewei Liang, Shuyan Qiu, Zhixin Zhang, Juan Ding, Yaling Li, Chunyan Zhang, Jin Fu, Daoxing He, Yanlin Zhou, Dongbo Li, Cesheng Zhang, Jiayou Yu, Ding Yang, Xiao-Ming |
author_facet | Liang, Hong Nian, Xuanxuan Wu, Junzheng Liu, Dong Feng, Lu Lu, Jia Peng, Yan Zhou, Zhijun Deng, Tao Liu, Jing Ji, Deming Qiu, Ran Lin, Lianzhen Zeng, Yan Xia, Fei Hu, Yong Li, Taojing Duan, Kai Li, Xinguo Wang, Zejun Zhang, Yong Zhang, Hang Zhu, Chen Wang, Shang Wu, Xiao Wang, Xiang Li, Yuwei Huang, Shihe Mao, Min Guo, Huanhuan Yang, Yunkai Jia, Rui Xufang, Jingwei Wang, Xuewei Liang, Shuyan Qiu, Zhixin Zhang, Juan Ding, Yaling Li, Chunyan Zhang, Jin Fu, Daoxing He, Yanlin Zhou, Dongbo Li, Cesheng Zhang, Jiayou Yu, Ding Yang, Xiao-Ming |
author_sort | Liang, Hong |
collection | PubMed |
description | The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4(+) T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants. |
format | Online Article Text |
id | pubmed-9734167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-97341672022-12-11 COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan Liang, Hong Nian, Xuanxuan Wu, Junzheng Liu, Dong Feng, Lu Lu, Jia Peng, Yan Zhou, Zhijun Deng, Tao Liu, Jing Ji, Deming Qiu, Ran Lin, Lianzhen Zeng, Yan Xia, Fei Hu, Yong Li, Taojing Duan, Kai Li, Xinguo Wang, Zejun Zhang, Yong Zhang, Hang Zhu, Chen Wang, Shang Wu, Xiao Wang, Xiang Li, Yuwei Huang, Shihe Mao, Min Guo, Huanhuan Yang, Yunkai Jia, Rui Xufang, Jingwei Wang, Xuewei Liang, Shuyan Qiu, Zhixin Zhang, Juan Ding, Yaling Li, Chunyan Zhang, Jin Fu, Daoxing He, Yanlin Zhou, Dongbo Li, Cesheng Zhang, Jiayou Yu, Ding Yang, Xiao-Ming Cell Discov Article The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4(+) T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants. Springer Nature Singapore 2022-12-09 /pmc/articles/PMC9734167/ /pubmed/36494338 http://dx.doi.org/10.1038/s41421-022-00496-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Liang, Hong Nian, Xuanxuan Wu, Junzheng Liu, Dong Feng, Lu Lu, Jia Peng, Yan Zhou, Zhijun Deng, Tao Liu, Jing Ji, Deming Qiu, Ran Lin, Lianzhen Zeng, Yan Xia, Fei Hu, Yong Li, Taojing Duan, Kai Li, Xinguo Wang, Zejun Zhang, Yong Zhang, Hang Zhu, Chen Wang, Shang Wu, Xiao Wang, Xiang Li, Yuwei Huang, Shihe Mao, Min Guo, Huanhuan Yang, Yunkai Jia, Rui Xufang, Jingwei Wang, Xuewei Liang, Shuyan Qiu, Zhixin Zhang, Juan Ding, Yaling Li, Chunyan Zhang, Jin Fu, Daoxing He, Yanlin Zhou, Dongbo Li, Cesheng Zhang, Jiayou Yu, Ding Yang, Xiao-Ming COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title_full | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title_fullStr | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title_full_unstemmed | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title_short | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
title_sort | covid-19 vaccination boosts the potency and breadth of the immune response against sars-cov-2 among recovered patients in wuhan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734167/ https://www.ncbi.nlm.nih.gov/pubmed/36494338 http://dx.doi.org/10.1038/s41421-022-00496-x |
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