Triazoles with inhibitory action on P2X7R impaired the acute inflammatory response in vivo and modulated the hemostatic balance in vitro and ex vivo

OBJECTIVE: The present study aimed to investigate five triazole compounds as P2X7R inhibitors and evaluate their ability to reduce acute inflammation in vivo. MATERIAL: The synthetic compounds were labeled 5e, 8h, 9i, 11, and 12. TREATMENT: We administered 500 ng/kg triazole analogs in vivo, (1–10 µ...

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Detalles Bibliográficos
Autores principales: Pinheiro, Nathalia Gugick, Gonzaga, Daniel Tadeu Gomes, da Silva, Aldo Rodrigues, Fuly, Andre Lopes, von Ranke, Natalia Lidmar, Rodrigues, Carlos Rangel, Magalhães, Betina Quintanilha, Pereira, Julianne Soares, Pacheco, Paulo Anastácio F., Silva, Ana Cláudia, Ferreira, Vitor Francisco, de Carvalho da Silva, Fernando, Faria, Robson Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734322/
https://www.ncbi.nlm.nih.gov/pubmed/36463339
http://dx.doi.org/10.1007/s00011-022-01664-1

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