Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain

Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especially the first and rate-limiting NADPH-producing enzyme glucose 6-phosphate dehydrogenase (G6PD), is considered an excellent antitrypanosomatid drug target. Here we present t...

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Detalles Bibliográficos
Autores principales: Berneburg, Isabell, Rahlfs, Stefan, Becker, Katja, Fritz-Wolf, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734377/
https://www.ncbi.nlm.nih.gov/pubmed/36494598
http://dx.doi.org/10.1038/s42003-022-04307-7

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