Mechanisms of circular RNA degradation

Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. W...

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Autores principales: Ren, Longxin, Jiang, Qingshan, Mo, Liyi, Tan, Lijie, Dong, Qifei, Meng, Lijuan, Yang, Nanyang, Li, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734648/
https://www.ncbi.nlm.nih.gov/pubmed/36494488
http://dx.doi.org/10.1038/s42003-022-04262-3
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author Ren, Longxin
Jiang, Qingshan
Mo, Liyi
Tan, Lijie
Dong, Qifei
Meng, Lijuan
Yang, Nanyang
Li, Guoqing
author_facet Ren, Longxin
Jiang, Qingshan
Mo, Liyi
Tan, Lijie
Dong, Qifei
Meng, Lijuan
Yang, Nanyang
Li, Guoqing
author_sort Ren, Longxin
collection PubMed
description Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.
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spelling pubmed-97346482022-12-11 Mechanisms of circular RNA degradation Ren, Longxin Jiang, Qingshan Mo, Liyi Tan, Lijie Dong, Qifei Meng, Lijuan Yang, Nanyang Li, Guoqing Commun Biol Perspective Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs. Nature Publishing Group UK 2022-12-09 /pmc/articles/PMC9734648/ /pubmed/36494488 http://dx.doi.org/10.1038/s42003-022-04262-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Ren, Longxin
Jiang, Qingshan
Mo, Liyi
Tan, Lijie
Dong, Qifei
Meng, Lijuan
Yang, Nanyang
Li, Guoqing
Mechanisms of circular RNA degradation
title Mechanisms of circular RNA degradation
title_full Mechanisms of circular RNA degradation
title_fullStr Mechanisms of circular RNA degradation
title_full_unstemmed Mechanisms of circular RNA degradation
title_short Mechanisms of circular RNA degradation
title_sort mechanisms of circular rna degradation
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734648/
https://www.ncbi.nlm.nih.gov/pubmed/36494488
http://dx.doi.org/10.1038/s42003-022-04262-3
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