SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

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Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of vascular leak are unclear. Here, we report that cel...

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Detalles Bibliográficos
Autores principales: Biering, Scott B., Gomes de Sousa, Francielle Tramontini, Tjang, Laurentia V., Pahmeier, Felix, Zhu, Chi, Ruan, Richard, Blanc, Sophie F., Patel, Trishna S., Worthington, Caroline M., Glasner, Dustin R., Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas T. N., Wong, Marcus P., Warnes, Colin M., Sandoval, Daniel R., Clausen, Thomas Mandel, Santos, Yale A., Fox, Douglas M., Ortega, Victoria, Näär, Anders M., Baric, Ralph S., Stanley, Sarah A., Aguilar, Hector C., Esko, Jeffrey D., Chiu, Charles Y., Pak, John E., Beatty, P. Robert, Harris, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734751/
https://www.ncbi.nlm.nih.gov/pubmed/36494335
http://dx.doi.org/10.1038/s41467-022-34910-5
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