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Phase angle and cellular health: inflammation and oxidative damage

Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle ha...

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Autores principales: da Silva¹, Bruna Ramos, Orsso¹, Camila E., Gonzalez², Maria Cristina, Sicchieri³, Juliana Maria Faccioli, Mialich³, Mirele Savegnago, Jordao³, Alceu A., Prado, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735064/
https://www.ncbi.nlm.nih.gov/pubmed/36474107
http://dx.doi.org/10.1007/s11154-022-09775-0
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author da Silva¹, Bruna Ramos
Orsso¹, Camila E.
Gonzalez², Maria Cristina
Sicchieri³, Juliana Maria Faccioli
Mialich³, Mirele Savegnago
Jordao³, Alceu A.
Prado, Carla M.
author_facet da Silva¹, Bruna Ramos
Orsso¹, Camila E.
Gonzalez², Maria Cristina
Sicchieri³, Juliana Maria Faccioli
Mialich³, Mirele Savegnago
Jordao³, Alceu A.
Prado, Carla M.
author_sort da Silva¹, Bruna Ramos
collection PubMed
description Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.
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spelling pubmed-97350642022-12-12 Phase angle and cellular health: inflammation and oxidative damage da Silva¹, Bruna Ramos Orsso¹, Camila E. Gonzalez², Maria Cristina Sicchieri³, Juliana Maria Faccioli Mialich³, Mirele Savegnago Jordao³, Alceu A. Prado, Carla M. Rev Endocr Metab Disord Article Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use. Springer US 2022-12-07 2023 /pmc/articles/PMC9735064/ /pubmed/36474107 http://dx.doi.org/10.1007/s11154-022-09775-0 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
da Silva¹, Bruna Ramos
Orsso¹, Camila E.
Gonzalez², Maria Cristina
Sicchieri³, Juliana Maria Faccioli
Mialich³, Mirele Savegnago
Jordao³, Alceu A.
Prado, Carla M.
Phase angle and cellular health: inflammation and oxidative damage
title Phase angle and cellular health: inflammation and oxidative damage
title_full Phase angle and cellular health: inflammation and oxidative damage
title_fullStr Phase angle and cellular health: inflammation and oxidative damage
title_full_unstemmed Phase angle and cellular health: inflammation and oxidative damage
title_short Phase angle and cellular health: inflammation and oxidative damage
title_sort phase angle and cellular health: inflammation and oxidative damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735064/
https://www.ncbi.nlm.nih.gov/pubmed/36474107
http://dx.doi.org/10.1007/s11154-022-09775-0
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