Liquid chromatography–tandem mass spectrometry for clinical diagnostics

Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spec...

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Autores principales: Thomas, Stefani N., French, Deborah, Jannetto, Paul J., Rappold, Brian A., Clarke, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735147/
https://www.ncbi.nlm.nih.gov/pubmed/36532107
http://dx.doi.org/10.1038/s43586-022-00175-x
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author Thomas, Stefani N.
French, Deborah
Jannetto, Paul J.
Rappold, Brian A.
Clarke, William A.
author_facet Thomas, Stefani N.
French, Deborah
Jannetto, Paul J.
Rappold, Brian A.
Clarke, William A.
author_sort Thomas, Stefani N.
collection PubMed
description Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spectrometry. We discuss experimental considerations and quality management, and provide an overview of some key applications in the clinic. Lastly, the Primer discusses significant challenges for implementation of mass spectrometry in clinical laboratories and provides an outlook of where there are emerging clinical applications for this technology.
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spelling pubmed-97351472022-12-12 Liquid chromatography–tandem mass spectrometry for clinical diagnostics Thomas, Stefani N. French, Deborah Jannetto, Paul J. Rappold, Brian A. Clarke, William A. Nat Rev Methods Primers Primer Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spectrometry. We discuss experimental considerations and quality management, and provide an overview of some key applications in the clinic. Lastly, the Primer discusses significant challenges for implementation of mass spectrometry in clinical laboratories and provides an outlook of where there are emerging clinical applications for this technology. Nature Publishing Group UK 2022-12-08 2022 /pmc/articles/PMC9735147/ /pubmed/36532107 http://dx.doi.org/10.1038/s43586-022-00175-x Text en © Springer Nature Limited 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Primer
Thomas, Stefani N.
French, Deborah
Jannetto, Paul J.
Rappold, Brian A.
Clarke, William A.
Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title_full Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title_fullStr Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title_full_unstemmed Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title_short Liquid chromatography–tandem mass spectrometry for clinical diagnostics
title_sort liquid chromatography–tandem mass spectrometry for clinical diagnostics
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735147/
https://www.ncbi.nlm.nih.gov/pubmed/36532107
http://dx.doi.org/10.1038/s43586-022-00175-x
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