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Immunomodulatory effects of atorvastatin on MRL/lpr mice

BACKGROUND: Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years. This study was designed to investigate the immunomodulatory effects of atorvastatin on lupus-prone MRL/lpr mice. METHODS: A t...

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Autores principales: Sun, Jing, Xu, Weidong, Wu, Zhiying, Cao, Caijin, Tan, Yane, Zhu, Meifang, Wu, Hongze, Yu, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735199/
https://www.ncbi.nlm.nih.gov/pubmed/36471414
http://dx.doi.org/10.1186/s42358-022-00282-z
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author Sun, Jing
Xu, Weidong
Wu, Zhiying
Cao, Caijin
Tan, Yane
Zhu, Meifang
Wu, Hongze
Yu, Jianping
author_facet Sun, Jing
Xu, Weidong
Wu, Zhiying
Cao, Caijin
Tan, Yane
Zhu, Meifang
Wu, Hongze
Yu, Jianping
author_sort Sun, Jing
collection PubMed
description BACKGROUND: Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years. This study was designed to investigate the immunomodulatory effects of atorvastatin on lupus-prone MRL/lpr mice. METHODS: A total of 30 8-week-old female MRL/lpr mice were randomly divided into three groups and orally administered vehicle, atorvastatin orhydroxychloroquine sulfate for 11 weeks. In vivo, the effects of atorvastatin on the survival rate, renal function and spleen index in MRL/lpr mice were examined. Ex vivo, splenic B-cell proliferation was assessed by a Cell Counting Kit-8. RESULTS: Oral atorvastatin failed to prolong survival time, or reduce the levels of proteinuria, or serum anti-dsDNA antibody and complement proteins (C3, C4). Histologically, no significant improvement by atorvastatin was observed in the pathological manifestations of renal damage, while hydroxychloroquine sulfate significantly improved glomerular injury. Ex vivo, atorvastatin suppressed the proliferation of splenic B lymphocytes. CONCLUSION: Oral atorvastatin monotherapy had no therapeutic effects on MRL/lpr mice, whereas atorvastatin inhibited splenic B-cell proliferation in vitro, suggesting that atorvastatin has a potential therapeutic effect on systemic lupus erythematosus.
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spelling pubmed-97351992022-12-12 Immunomodulatory effects of atorvastatin on MRL/lpr mice Sun, Jing Xu, Weidong Wu, Zhiying Cao, Caijin Tan, Yane Zhu, Meifang Wu, Hongze Yu, Jianping Adv Rheumatol Research BACKGROUND: Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years. This study was designed to investigate the immunomodulatory effects of atorvastatin on lupus-prone MRL/lpr mice. METHODS: A total of 30 8-week-old female MRL/lpr mice were randomly divided into three groups and orally administered vehicle, atorvastatin orhydroxychloroquine sulfate for 11 weeks. In vivo, the effects of atorvastatin on the survival rate, renal function and spleen index in MRL/lpr mice were examined. Ex vivo, splenic B-cell proliferation was assessed by a Cell Counting Kit-8. RESULTS: Oral atorvastatin failed to prolong survival time, or reduce the levels of proteinuria, or serum anti-dsDNA antibody and complement proteins (C3, C4). Histologically, no significant improvement by atorvastatin was observed in the pathological manifestations of renal damage, while hydroxychloroquine sulfate significantly improved glomerular injury. Ex vivo, atorvastatin suppressed the proliferation of splenic B lymphocytes. CONCLUSION: Oral atorvastatin monotherapy had no therapeutic effects on MRL/lpr mice, whereas atorvastatin inhibited splenic B-cell proliferation in vitro, suggesting that atorvastatin has a potential therapeutic effect on systemic lupus erythematosus. BioMed Central 2022-12-05 2022 /pmc/articles/PMC9735199/ /pubmed/36471414 http://dx.doi.org/10.1186/s42358-022-00282-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Sun, Jing
Xu, Weidong
Wu, Zhiying
Cao, Caijin
Tan, Yane
Zhu, Meifang
Wu, Hongze
Yu, Jianping
Immunomodulatory effects of atorvastatin on MRL/lpr mice
title Immunomodulatory effects of atorvastatin on MRL/lpr mice
title_full Immunomodulatory effects of atorvastatin on MRL/lpr mice
title_fullStr Immunomodulatory effects of atorvastatin on MRL/lpr mice
title_full_unstemmed Immunomodulatory effects of atorvastatin on MRL/lpr mice
title_short Immunomodulatory effects of atorvastatin on MRL/lpr mice
title_sort immunomodulatory effects of atorvastatin on mrl/lpr mice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735199/
https://www.ncbi.nlm.nih.gov/pubmed/36471414
http://dx.doi.org/10.1186/s42358-022-00282-z
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