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Structural Landscape of nsp Coding Genomic Regions of SARS-CoV-2-ssRNA Genome: A Structural Genomics Approach Toward Identification of Druggable Genome, Ligand-Binding Pockets, and Structure-Based Druggability

SARS-CoV-2 has a single-stranded RNA genome (+ssRNA), and synthesizes structural and non-structural proteins (nsps). All 16 nsp are synthesized from the ORF1a, and ORF1b regions associated with different life cycle preprocesses, including replication. The regions of ORF1a synthesizes nsp1 to 11, and...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Chiranjib, Bhattacharya, Manojit, Sharma, Ashish Ranjan, Chatterjee, Srijan, Agoramoorthy, Govindasamy, Lee, Sang-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735222/ https://www.ncbi.nlm.nih.gov/pubmed/36463562 http://dx.doi.org/10.1007/s12033-022-00605-x

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