The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and infective exacerbations, however, in-vitro model systems for the study of host-pathogen interaction at the individual level are lacking. Here, we describe the establishment of nasopharyngeal and bronchial organoi...

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Detalles Bibliográficos
Autores principales: Chan, Louisa L. Y., Anderson, Danielle E., Cheng, Hong Sheng, Ivan, Fransiskus Xaverius, Chen, Si, Kang, Adrian E. Z., Foo, Randy, Gamage, Akshamal M., Tiew, Pei Yee, Koh, Mariko Siyue, Lee, Ken Cheah Hooi, Nichol, Kristy, Pathinayake, Prabuddha S., Chan, Yik Lung, Yeo, Tsin Wen, Oliver, Brian G., Wark, Peter A. B., Liu, Linbo, Tan, Nguan Soon, Wang, Lin-Fa, Chotirmall, Sanjay H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735280/
https://www.ncbi.nlm.nih.gov/pubmed/36496442
http://dx.doi.org/10.1038/s41467-022-35253-x

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