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Does long‐term phenytoin have a place in Dravet syndrome?

Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet syndrome. We describe four pati...

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Detalles Bibliográficos
Autores principales: Zographos, George A., Russ‐Hall, Sophie J., Scheffer, Ingrid E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735367/
https://www.ncbi.nlm.nih.gov/pubmed/36314457
http://dx.doi.org/10.1002/acn3.51684
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author Zographos, George A.
Russ‐Hall, Sophie J.
Scheffer, Ingrid E.
author_facet Zographos, George A.
Russ‐Hall, Sophie J.
Scheffer, Ingrid E.
author_sort Zographos, George A.
collection PubMed
description Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet syndrome. We describe four patients with Dravet syndrome in whom long‐term phenytoin therapy reduced seizure frequency and duration. In two patients, phenytoin produced prolonged periods without status epilepticus for the first time. Attempting to wean phenytoin in all patients after 1 to 20 years of use resulted in seizure exacerbation. Reintroducing phenytoin improved seizure control, suggesting phenytoin is beneficial in some patients with Dravet syndrome.
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spelling pubmed-97353672022-12-12 Does long‐term phenytoin have a place in Dravet syndrome? Zographos, George A. Russ‐Hall, Sophie J. Scheffer, Ingrid E. Ann Clin Transl Neurol Brief Communications Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet syndrome. We describe four patients with Dravet syndrome in whom long‐term phenytoin therapy reduced seizure frequency and duration. In two patients, phenytoin produced prolonged periods without status epilepticus for the first time. Attempting to wean phenytoin in all patients after 1 to 20 years of use resulted in seizure exacerbation. Reintroducing phenytoin improved seizure control, suggesting phenytoin is beneficial in some patients with Dravet syndrome. John Wiley and Sons Inc. 2022-10-31 /pmc/articles/PMC9735367/ /pubmed/36314457 http://dx.doi.org/10.1002/acn3.51684 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Zographos, George A.
Russ‐Hall, Sophie J.
Scheffer, Ingrid E.
Does long‐term phenytoin have a place in Dravet syndrome?
title Does long‐term phenytoin have a place in Dravet syndrome?
title_full Does long‐term phenytoin have a place in Dravet syndrome?
title_fullStr Does long‐term phenytoin have a place in Dravet syndrome?
title_full_unstemmed Does long‐term phenytoin have a place in Dravet syndrome?
title_short Does long‐term phenytoin have a place in Dravet syndrome?
title_sort does long‐term phenytoin have a place in dravet syndrome?
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735367/
https://www.ncbi.nlm.nih.gov/pubmed/36314457
http://dx.doi.org/10.1002/acn3.51684
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