Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS

The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applie...

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Detalles Bibliográficos
Autores principales: Rummey, Christian, Harding, Ian H., Delatycki, Martin B., Tai, Geneieve, Rezende, Thiago, Corben, Louise A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735370/
https://www.ncbi.nlm.nih.gov/pubmed/36394163
http://dx.doi.org/10.1002/acn3.51686
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author Rummey, Christian
Harding, Ian H.
Delatycki, Martin B.
Tai, Geneieve
Rezende, Thiago
Corben, Louise A.
author_facet Rummey, Christian
Harding, Ian H.
Delatycki, Martin B.
Tai, Geneieve
Rezende, Thiago
Corben, Louise A.
author_sort Rummey, Christian
collection PubMed
description The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applied the modified Friedreich Ataxia Rating Scale (mFARS), the Scale for the Assessment and Rating of Ataxia (SARA), and the International Cooperative Ataxia Rating Scale (ICARS) to a large cohort of people with Friedreich's ataxia. We provide regression coefficients for scale interconversion and discuss the reliability of this approach, together with insights into the differential sensitivities of mFARS and SARA to disease progression.
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spelling pubmed-97353702022-12-12 Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS Rummey, Christian Harding, Ian H. Delatycki, Martin B. Tai, Geneieve Rezende, Thiago Corben, Louise A. Ann Clin Transl Neurol Brief Communications The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applied the modified Friedreich Ataxia Rating Scale (mFARS), the Scale for the Assessment and Rating of Ataxia (SARA), and the International Cooperative Ataxia Rating Scale (ICARS) to a large cohort of people with Friedreich's ataxia. We provide regression coefficients for scale interconversion and discuss the reliability of this approach, together with insights into the differential sensitivities of mFARS and SARA to disease progression. John Wiley and Sons Inc. 2022-11-16 /pmc/articles/PMC9735370/ /pubmed/36394163 http://dx.doi.org/10.1002/acn3.51686 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Rummey, Christian
Harding, Ian H.
Delatycki, Martin B.
Tai, Geneieve
Rezende, Thiago
Corben, Louise A.
Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title_full Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title_fullStr Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title_full_unstemmed Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title_short Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
title_sort harmonizing results of ataxia rating scales: mfars, sara, and icars
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735370/
https://www.ncbi.nlm.nih.gov/pubmed/36394163
http://dx.doi.org/10.1002/acn3.51686
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