Methotrexate-Induced Liver Injury Is Associated with Oxidative Stress, Impaired Mitochondrial Respiration, and Endoplasmic Reticulum Stress In Vitro

Low-dose methotrexate (MTX) is a standard therapy for rheumatoid arthritis due to its low cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug-induced liver injury, namely liver fibrosis. The hallmark of liver fibrosis is excessive scarring of liver tissue, triggere...

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Detalles Bibliográficos
Autores principales: Schmidt, Saskia, Messner, Catherine Jane, Gaiser, Carine, Hämmerli, Carina, Suter-Dick, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735468/
https://www.ncbi.nlm.nih.gov/pubmed/36499436
http://dx.doi.org/10.3390/ijms232315116

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