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Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients

Immunosenescence encompasses a spectrum of lymphocyte phenotypic alterations. The aim of the study was to evaluate immunosenescent effect of two different forms of chronic inflammation, Systemic Lupus Erythematosous (SLE), a systemic autoimmune disease, and End-Stage Kidney Disease (ESKD), a chronic...

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Autores principales: Moysidou, Eleni, Lioulios, Georgios, Xochelli, Aliki, Nikolaidou, Vasiliki, Christodoulou, Michalis, Mitsoglou, Zoi, Stai, Stamatia, Fylaktou, Asimina, Papagianni, Aikaterini, Stangou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735546/
https://www.ncbi.nlm.nih.gov/pubmed/36499016
http://dx.doi.org/10.3390/ijms232314688
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author Moysidou, Eleni
Lioulios, Georgios
Xochelli, Aliki
Nikolaidou, Vasiliki
Christodoulou, Michalis
Mitsoglou, Zoi
Stai, Stamatia
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
author_facet Moysidou, Eleni
Lioulios, Georgios
Xochelli, Aliki
Nikolaidou, Vasiliki
Christodoulou, Michalis
Mitsoglou, Zoi
Stai, Stamatia
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
author_sort Moysidou, Eleni
collection PubMed
description Immunosenescence encompasses a spectrum of lymphocyte phenotypic alterations. The aim of the study was to evaluate immunosenescent effect of two different forms of chronic inflammation, Systemic Lupus Erythematosous (SLE), a systemic autoimmune disease, and End-Stage Kidney Disease (ESKD), a chronic inflammatory disorder. Certain lymphocyte surface molecules, including CD31, CD45RA, CCR7, CD28, CD57, for T, and IgD, CD27 for B lymphocytes, were analyzed by flow cytometry in 30 SLE and 53 ESKD patients on hemodialysis (HD), and results were compared to 31 healthy controls (HC) of similar age, gender, and nationality. Significant Lymphopenia was evident in both SLE and ESKD-HD patients, compared to HC, affecting B cells 75.4 (14.4–520.8), 97 (32–341), and 214 (84–576) cells/μL, respectively, p < 0.0001, and CD4 cells 651.2 (71.1–1478.2), 713 (234–1509), and 986 (344–1591) cells/μL, respectively, p < 0.0001. The allocation of B cell subpopulations was remarkably different between SLE and ESKD-HD patients. SLE showed a clear shift to senescence (CD19IgD-CD27−) cells, compared to ESKD-HD and HC, 11.75 (10)% vs. 8 (6) vs. 8.1 (10), respectively. Regarding T lymphocytes, Central Memory CD8 cells predominated in both SLE and ESKD-HD patients compared to HC, 53 (50)%, 52 (63), and 24 (64)%, respectively, while ESKD-HD but not SLE patients also had increased expression of CD4CD28− and CD8CD28− cells. In conclusion, both diseases are followed by significant lymphopenia; however, the senescent phenomenon affects the B lymphocyte compartment in SLE patients and T lymphocytes in ESKD-HD patients.
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spelling pubmed-97355462022-12-11 Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients Moysidou, Eleni Lioulios, Georgios Xochelli, Aliki Nikolaidou, Vasiliki Christodoulou, Michalis Mitsoglou, Zoi Stai, Stamatia Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria Int J Mol Sci Article Immunosenescence encompasses a spectrum of lymphocyte phenotypic alterations. The aim of the study was to evaluate immunosenescent effect of two different forms of chronic inflammation, Systemic Lupus Erythematosous (SLE), a systemic autoimmune disease, and End-Stage Kidney Disease (ESKD), a chronic inflammatory disorder. Certain lymphocyte surface molecules, including CD31, CD45RA, CCR7, CD28, CD57, for T, and IgD, CD27 for B lymphocytes, were analyzed by flow cytometry in 30 SLE and 53 ESKD patients on hemodialysis (HD), and results were compared to 31 healthy controls (HC) of similar age, gender, and nationality. Significant Lymphopenia was evident in both SLE and ESKD-HD patients, compared to HC, affecting B cells 75.4 (14.4–520.8), 97 (32–341), and 214 (84–576) cells/μL, respectively, p < 0.0001, and CD4 cells 651.2 (71.1–1478.2), 713 (234–1509), and 986 (344–1591) cells/μL, respectively, p < 0.0001. The allocation of B cell subpopulations was remarkably different between SLE and ESKD-HD patients. SLE showed a clear shift to senescence (CD19IgD-CD27−) cells, compared to ESKD-HD and HC, 11.75 (10)% vs. 8 (6) vs. 8.1 (10), respectively. Regarding T lymphocytes, Central Memory CD8 cells predominated in both SLE and ESKD-HD patients compared to HC, 53 (50)%, 52 (63), and 24 (64)%, respectively, while ESKD-HD but not SLE patients also had increased expression of CD4CD28− and CD8CD28− cells. In conclusion, both diseases are followed by significant lymphopenia; however, the senescent phenomenon affects the B lymphocyte compartment in SLE patients and T lymphocytes in ESKD-HD patients. MDPI 2022-11-24 /pmc/articles/PMC9735546/ /pubmed/36499016 http://dx.doi.org/10.3390/ijms232314688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moysidou, Eleni
Lioulios, Georgios
Xochelli, Aliki
Nikolaidou, Vasiliki
Christodoulou, Michalis
Mitsoglou, Zoi
Stai, Stamatia
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title_full Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title_fullStr Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title_full_unstemmed Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title_short Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients
title_sort different types of chronic inflammation engender distinctive immunosenescent profiles in affected patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735546/
https://www.ncbi.nlm.nih.gov/pubmed/36499016
http://dx.doi.org/10.3390/ijms232314688
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