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Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal h...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735563/ https://www.ncbi.nlm.nih.gov/pubmed/36501107 http://dx.doi.org/10.3390/nu14235077 |
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author | García-Rodríguez, Paula Ma, Feifei del Río, Carmen Romero-Bernal, Marina Najar, Ana M. Cádiz-Gurrea, María de la Luz Leyva-Jimenez, Francisco Javier Ramiro, Laura Menéndez-Valladares, Paloma Pérez-Sánchez, Soledad Segura-Carretero, Antonio Montaner, Joan |
author_facet | García-Rodríguez, Paula Ma, Feifei del Río, Carmen Romero-Bernal, Marina Najar, Ana M. Cádiz-Gurrea, María de la Luz Leyva-Jimenez, Francisco Javier Ramiro, Laura Menéndez-Valladares, Paloma Pérez-Sánchez, Soledad Segura-Carretero, Antonio Montaner, Joan |
author_sort | García-Rodríguez, Paula |
collection | PubMed |
description | Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia–reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders. |
format | Online Article Text |
id | pubmed-9735563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97355632022-12-11 Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia García-Rodríguez, Paula Ma, Feifei del Río, Carmen Romero-Bernal, Marina Najar, Ana M. Cádiz-Gurrea, María de la Luz Leyva-Jimenez, Francisco Javier Ramiro, Laura Menéndez-Valladares, Paloma Pérez-Sánchez, Soledad Segura-Carretero, Antonio Montaner, Joan Nutrients Article Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia–reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders. MDPI 2022-11-29 /pmc/articles/PMC9735563/ /pubmed/36501107 http://dx.doi.org/10.3390/nu14235077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Rodríguez, Paula Ma, Feifei del Río, Carmen Romero-Bernal, Marina Najar, Ana M. Cádiz-Gurrea, María de la Luz Leyva-Jimenez, Francisco Javier Ramiro, Laura Menéndez-Valladares, Paloma Pérez-Sánchez, Soledad Segura-Carretero, Antonio Montaner, Joan Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title | Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title_full | Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title_fullStr | Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title_full_unstemmed | Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title_short | Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia |
title_sort | diet supplementation with polyphenol-rich salicornia ramosissima extracts protects against tissue damage in experimental models of cerebral ischemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735563/ https://www.ncbi.nlm.nih.gov/pubmed/36501107 http://dx.doi.org/10.3390/nu14235077 |
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