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Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia

Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal h...

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Autores principales: García-Rodríguez, Paula, Ma, Feifei, del Río, Carmen, Romero-Bernal, Marina, Najar, Ana M., Cádiz-Gurrea, María de la Luz, Leyva-Jimenez, Francisco Javier, Ramiro, Laura, Menéndez-Valladares, Paloma, Pérez-Sánchez, Soledad, Segura-Carretero, Antonio, Montaner, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735563/
https://www.ncbi.nlm.nih.gov/pubmed/36501107
http://dx.doi.org/10.3390/nu14235077
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author García-Rodríguez, Paula
Ma, Feifei
del Río, Carmen
Romero-Bernal, Marina
Najar, Ana M.
Cádiz-Gurrea, María de la Luz
Leyva-Jimenez, Francisco Javier
Ramiro, Laura
Menéndez-Valladares, Paloma
Pérez-Sánchez, Soledad
Segura-Carretero, Antonio
Montaner, Joan
author_facet García-Rodríguez, Paula
Ma, Feifei
del Río, Carmen
Romero-Bernal, Marina
Najar, Ana M.
Cádiz-Gurrea, María de la Luz
Leyva-Jimenez, Francisco Javier
Ramiro, Laura
Menéndez-Valladares, Paloma
Pérez-Sánchez, Soledad
Segura-Carretero, Antonio
Montaner, Joan
author_sort García-Rodríguez, Paula
collection PubMed
description Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia–reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders.
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spelling pubmed-97355632022-12-11 Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia García-Rodríguez, Paula Ma, Feifei del Río, Carmen Romero-Bernal, Marina Najar, Ana M. Cádiz-Gurrea, María de la Luz Leyva-Jimenez, Francisco Javier Ramiro, Laura Menéndez-Valladares, Paloma Pérez-Sánchez, Soledad Segura-Carretero, Antonio Montaner, Joan Nutrients Article Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia–reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders. MDPI 2022-11-29 /pmc/articles/PMC9735563/ /pubmed/36501107 http://dx.doi.org/10.3390/nu14235077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Rodríguez, Paula
Ma, Feifei
del Río, Carmen
Romero-Bernal, Marina
Najar, Ana M.
Cádiz-Gurrea, María de la Luz
Leyva-Jimenez, Francisco Javier
Ramiro, Laura
Menéndez-Valladares, Paloma
Pérez-Sánchez, Soledad
Segura-Carretero, Antonio
Montaner, Joan
Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title_full Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title_fullStr Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title_full_unstemmed Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title_short Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia
title_sort diet supplementation with polyphenol-rich salicornia ramosissima extracts protects against tissue damage in experimental models of cerebral ischemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735563/
https://www.ncbi.nlm.nih.gov/pubmed/36501107
http://dx.doi.org/10.3390/nu14235077
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