Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release

Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake i...

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Detalles Bibliográficos
Autores principales: Horbay, Rostyslav, Hamraghani, Ali, Ermini, Leonardo, Holcik, Sophie, Beug, Shawn T., Yeganeh, Behzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735581/
https://www.ncbi.nlm.nih.gov/pubmed/36499644
http://dx.doi.org/10.3390/ijms232315317
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author Horbay, Rostyslav
Hamraghani, Ali
Ermini, Leonardo
Holcik, Sophie
Beug, Shawn T.
Yeganeh, Behzad
author_facet Horbay, Rostyslav
Hamraghani, Ali
Ermini, Leonardo
Holcik, Sophie
Beug, Shawn T.
Yeganeh, Behzad
author_sort Horbay, Rostyslav
collection PubMed
description Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake.
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spelling pubmed-97355812022-12-11 Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release Horbay, Rostyslav Hamraghani, Ali Ermini, Leonardo Holcik, Sophie Beug, Shawn T. Yeganeh, Behzad Int J Mol Sci Review Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake. MDPI 2022-12-05 /pmc/articles/PMC9735581/ /pubmed/36499644 http://dx.doi.org/10.3390/ijms232315317 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Horbay, Rostyslav
Hamraghani, Ali
Ermini, Leonardo
Holcik, Sophie
Beug, Shawn T.
Yeganeh, Behzad
Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title_full Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title_fullStr Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title_full_unstemmed Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title_short Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
title_sort role of ceramides and lysosomes in extracellular vesicle biogenesis, cargo sorting and release
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735581/
https://www.ncbi.nlm.nih.gov/pubmed/36499644
http://dx.doi.org/10.3390/ijms232315317
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