Cargando…

Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2

The mechanisms underlying the neuroprotective effects of the hybrid antioxidant-nitric oxide donating compound SA-2 in retinal ganglion cell (RGC) degeneration models were evaluated. The in vitro trophic factor (TF) deprivation model in primary rat RGCs and ex vivo human retinal explants were used t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pham, Jennifer H., Johnson, Gretchen A., Rangan, Rajiv S., Amankwa, Charles E., Acharya, Suchismita, Stankowska, Dorota L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735605/ https://www.ncbi.nlm.nih.gov/pubmed/36497005 http://dx.doi.org/10.3390/cells11233741

Ejemplares similares

Modulation of Mitochondrial Metabolic Parameters and Antioxidant Enzymes in Healthy and Glaucomatous Trabecular Meshwork Cells with Hybrid Small Molecule SA-2
por: Amankwa, Charles E., et al.
Publicado: (2023)

Nanoencapsulated hybrid compound SA-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
por: Stankowska, Dorota L., et al.
Publicado: (2021)

Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma
por: Nam, Mi-Hyun, et al.
Publicado: (2022)

Mitochondria-associated endoplasmic reticulum membranes (MAMs) and their role in glaucomatous retinal ganglion cell degeneration—a mini review
por: Pham, Jennifer H., et al.
Publicado: (2023)

Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
por: Stankowska, Dorota L., et al.
Publicado: (2019)

Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
por: Stankowska, Dorota L., et al.
Publicado: (2019)

Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future
por: Amankwa, Charles E., et al.
Publicado: (2023)

Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma
por: Amankwa, Charles E., et al.
Publicado: (2021)

Oral administration of a dual ET(A)/ET(B) receptor antagonist promotes neuroprotection in a rodent model of glaucoma
por: Kodati, Bindu, et al.
Publicado: (2022)

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells
por: Kodati, Bindu, et al.
Publicado: (2021)

Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells
por: Chaphalkar, Renuka M., et al.
Publicado: (2020)

Taurine Provides Neuroprotection against Retinal Ganglion Cell Degeneration
por: Froger, Nicolas, et al.
Publicado: (2012)

p58(IPK) Is an Endogenous Neuroprotectant for Retinal Ganglion Cells
por: McLaughlin, Todd, et al.
Publicado: (2018)

Brimonidine is Neuroprotective in Animal Paradigm of Retinal Ganglion Cell Damage
por: Conti, Federica, et al.
Publicado: (2021)

Intrinsic Photosensitive Retinal Ganglion Cells in the Diurnal Rodent, Arvicanthis ansorgei
por: Karnas, Diana, et al.
Publicado: (2013)

Neuroprotection of a Novel Cyclopeptide C*HSDGIC* from the Cyclization of PACAP (1–5) in Cellular and Rodent Models of Retinal Ganglion Cell Apoptosis
por: Cheng, Huanhuan, et al.
Publicado: (2014)

Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2
por: Vigneswara, V, et al.
Publicado: (2016)

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration
por: Pietrucha-Dutczak, Marita, et al.
Publicado: (2018)

VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons
por: Froger, Nicolas, et al.
Publicado: (2020)

Neuroprotection by Wld(S) depends on retinal ganglion cell type and age in glaucoma
por: Risner, Michael L., et al.
Publicado: (2021)

Endothelin B Receptors Contribute to Retinal Ganglion Cell Loss in a Rat Model of Glaucoma
por: Minton, Alena Z., et al.
Publicado: (2012)

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
por: Nahomi, Rooban B., et al.
Publicado: (2020)

Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration
por: Mead, Ben, et al.
Publicado: (2015)

Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury
por: Xu, Lifang, et al.
Publicado: (2016)

The neuroprotective effect of resveratrol on retinal ganglion cells after optic nerve transection
por: Kim, Seok Hwan, et al.
Publicado: (2013)

Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release
por: Stifter, Julia, et al.
Publicado: (2017)

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead
por: Boia, Raquel, et al.
Publicado: (2020)

Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention
por: Vernazza, Stefania, et al.
Publicado: (2021)

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
por: Hu, Yue, et al.
Publicado: (2021)

In utero and ex vivo Electroporation for Gene Expression in Mouse Retinal Ganglion Cells
por: Petros, Timothy J, et al.
Publicado: (2009)

Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina
por: Croteau, Louis-Philippe, et al.
Publicado: (2022)

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
por: Tulsawani, Rajkumar, et al.
Publicado: (2010)

Neuroprotective and neurite outgrowth effects of maltol on retinal ganglion cells under oxidative stress
por: Hong, Samin, et al.
Publicado: (2014)

Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors
por: Linn, Cindy L.
Publicado: (2016)

Use of Gene Therapy in Retinal Ganglion Cell Neuroprotection: Current Concepts and Future Directions
por: Rhee, Jess, et al.
Publicado: (2021)

Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
por: Bastola, Tonking, et al.
Publicado: (2023)

Neuroprotection of Retinal Ganglion Cells Suppresses Microglia Activation in a Mouse Model of Glaucoma
por: Kumar, Sandeep, et al.
Publicado: (2023)

Intravitreal injection of forskolin, homotaurine, and L-carnosine affords neuroprotection to retinal ganglion cells following retinal ischemic injury
por: Russo, Rossella, et al.
Publicado: (2015)

Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress–induced retinal ganglion cell death
por: Nakayama, Mao, et al.
Publicado: (2011)

Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage
por: Fang, Jia Hua, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_8n26uao0jbas6o7i6v272nij4i