Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization

Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this...

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Autores principales: Wu, Jiaqi, Ma, Xiaoyu, Lu, Yu, Zhang, Tao, Du, Zuoqin, Xu, Jin, You, Jingcan, Chen, Ni, Deng, Xin, Wu, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735656/
https://www.ncbi.nlm.nih.gov/pubmed/36500277
http://dx.doi.org/10.3390/molecules27238184
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author Wu, Jiaqi
Ma, Xiaoyu
Lu, Yu
Zhang, Tao
Du, Zuoqin
Xu, Jin
You, Jingcan
Chen, Ni
Deng, Xin
Wu, Jianbo
author_facet Wu, Jiaqi
Ma, Xiaoyu
Lu, Yu
Zhang, Tao
Du, Zuoqin
Xu, Jin
You, Jingcan
Chen, Ni
Deng, Xin
Wu, Jianbo
author_sort Wu, Jiaqi
collection PubMed
description Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of P. lobata-derived exosomes (Exos) in isolated mouse macrophages. Our results show that P. lobata-derived Exos shift M1 macrophages toward the M2. These data present that P. lobata and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of P. lobata as novel an anti-inflammatory therapeutic biomaterial.
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spelling pubmed-97356562022-12-11 Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization Wu, Jiaqi Ma, Xiaoyu Lu, Yu Zhang, Tao Du, Zuoqin Xu, Jin You, Jingcan Chen, Ni Deng, Xin Wu, Jianbo Molecules Brief Report Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of P. lobata-derived exosomes (Exos) in isolated mouse macrophages. Our results show that P. lobata-derived Exos shift M1 macrophages toward the M2. These data present that P. lobata and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of P. lobata as novel an anti-inflammatory therapeutic biomaterial. MDPI 2022-11-24 /pmc/articles/PMC9735656/ /pubmed/36500277 http://dx.doi.org/10.3390/molecules27238184 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Wu, Jiaqi
Ma, Xiaoyu
Lu, Yu
Zhang, Tao
Du, Zuoqin
Xu, Jin
You, Jingcan
Chen, Ni
Deng, Xin
Wu, Jianbo
Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title_full Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title_fullStr Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title_full_unstemmed Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title_short Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
title_sort edible pueraria lobata-derived exosomes promote m2 macrophage polarization
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735656/
https://www.ncbi.nlm.nih.gov/pubmed/36500277
http://dx.doi.org/10.3390/molecules27238184
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