Cargando…

Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women

Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for S...

Descripción completa

Detalles Bibliográficos
Autores principales: Vásquez-Procopio, Johana, Torres-Torres, Johnatan, Borboa-Olivares, Hector, Sosa, Salvador Espino Y, Martínez-Portilla, Raigam Jafet, Solis-Paredes, Mario, Tolentino-Dolores, Mari-Cruz, Helguera-Repetto, Addy Cecilia, Marrufo-Gallegos, Karla Cecilia, Missirlis, Fanis, Perichart-Perera, Otilia, Estrada-Gutierrez, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735729/
https://www.ncbi.nlm.nih.gov/pubmed/36499537
http://dx.doi.org/10.3390/ijms232315188
_version_ 1784846842980204544
author Vásquez-Procopio, Johana
Torres-Torres, Johnatan
Borboa-Olivares, Hector
Sosa, Salvador Espino Y
Martínez-Portilla, Raigam Jafet
Solis-Paredes, Mario
Tolentino-Dolores, Mari-Cruz
Helguera-Repetto, Addy Cecilia
Marrufo-Gallegos, Karla Cecilia
Missirlis, Fanis
Perichart-Perera, Otilia
Estrada-Gutierrez, Guadalupe
author_facet Vásquez-Procopio, Johana
Torres-Torres, Johnatan
Borboa-Olivares, Hector
Sosa, Salvador Espino Y
Martínez-Portilla, Raigam Jafet
Solis-Paredes, Mario
Tolentino-Dolores, Mari-Cruz
Helguera-Repetto, Addy Cecilia
Marrufo-Gallegos, Karla Cecilia
Missirlis, Fanis
Perichart-Perera, Otilia
Estrada-Gutierrez, Guadalupe
author_sort Vásquez-Procopio, Johana
collection PubMed
description Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.
format Online
Article
Text
id pubmed-9735729
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97357292022-12-11 Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women Vásquez-Procopio, Johana Torres-Torres, Johnatan Borboa-Olivares, Hector Sosa, Salvador Espino Y Martínez-Portilla, Raigam Jafet Solis-Paredes, Mario Tolentino-Dolores, Mari-Cruz Helguera-Repetto, Addy Cecilia Marrufo-Gallegos, Karla Cecilia Missirlis, Fanis Perichart-Perera, Otilia Estrada-Gutierrez, Guadalupe Int J Mol Sci Communication Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy. MDPI 2022-12-02 /pmc/articles/PMC9735729/ /pubmed/36499537 http://dx.doi.org/10.3390/ijms232315188 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Vásquez-Procopio, Johana
Torres-Torres, Johnatan
Borboa-Olivares, Hector
Sosa, Salvador Espino Y
Martínez-Portilla, Raigam Jafet
Solis-Paredes, Mario
Tolentino-Dolores, Mari-Cruz
Helguera-Repetto, Addy Cecilia
Marrufo-Gallegos, Karla Cecilia
Missirlis, Fanis
Perichart-Perera, Otilia
Estrada-Gutierrez, Guadalupe
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title_full Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title_fullStr Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title_full_unstemmed Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title_short Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
title_sort association between 25-oh vitamin d deficiency and covid-19 severity in pregnant women
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735729/
https://www.ncbi.nlm.nih.gov/pubmed/36499537
http://dx.doi.org/10.3390/ijms232315188
work_keys_str_mv AT vasquezprocopiojohana associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT torrestorresjohnatan associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT borboaolivareshector associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT sosasalvadorespinoy associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT martinezportillaraigamjafet associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT solisparedesmario associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT tolentinodoloresmaricruz associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT helguerarepettoaddycecilia associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT marrufogallegoskarlacecilia associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT missirlisfanis associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT perichartpereraotilia associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen
AT estradagutierrezguadalupe associationbetween25ohvitaminddeficiencyandcovid19severityinpregnantwomen