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Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for S...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735729/ https://www.ncbi.nlm.nih.gov/pubmed/36499537 http://dx.doi.org/10.3390/ijms232315188 |
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author | Vásquez-Procopio, Johana Torres-Torres, Johnatan Borboa-Olivares, Hector Sosa, Salvador Espino Y Martínez-Portilla, Raigam Jafet Solis-Paredes, Mario Tolentino-Dolores, Mari-Cruz Helguera-Repetto, Addy Cecilia Marrufo-Gallegos, Karla Cecilia Missirlis, Fanis Perichart-Perera, Otilia Estrada-Gutierrez, Guadalupe |
author_facet | Vásquez-Procopio, Johana Torres-Torres, Johnatan Borboa-Olivares, Hector Sosa, Salvador Espino Y Martínez-Portilla, Raigam Jafet Solis-Paredes, Mario Tolentino-Dolores, Mari-Cruz Helguera-Repetto, Addy Cecilia Marrufo-Gallegos, Karla Cecilia Missirlis, Fanis Perichart-Perera, Otilia Estrada-Gutierrez, Guadalupe |
author_sort | Vásquez-Procopio, Johana |
collection | PubMed |
description | Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy. |
format | Online Article Text |
id | pubmed-9735729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97357292022-12-11 Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women Vásquez-Procopio, Johana Torres-Torres, Johnatan Borboa-Olivares, Hector Sosa, Salvador Espino Y Martínez-Portilla, Raigam Jafet Solis-Paredes, Mario Tolentino-Dolores, Mari-Cruz Helguera-Repetto, Addy Cecilia Marrufo-Gallegos, Karla Cecilia Missirlis, Fanis Perichart-Perera, Otilia Estrada-Gutierrez, Guadalupe Int J Mol Sci Communication Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy. MDPI 2022-12-02 /pmc/articles/PMC9735729/ /pubmed/36499537 http://dx.doi.org/10.3390/ijms232315188 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Vásquez-Procopio, Johana Torres-Torres, Johnatan Borboa-Olivares, Hector Sosa, Salvador Espino Y Martínez-Portilla, Raigam Jafet Solis-Paredes, Mario Tolentino-Dolores, Mari-Cruz Helguera-Repetto, Addy Cecilia Marrufo-Gallegos, Karla Cecilia Missirlis, Fanis Perichart-Perera, Otilia Estrada-Gutierrez, Guadalupe Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title | Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title_full | Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title_fullStr | Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title_full_unstemmed | Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title_short | Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women |
title_sort | association between 25-oh vitamin d deficiency and covid-19 severity in pregnant women |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735729/ https://www.ncbi.nlm.nih.gov/pubmed/36499537 http://dx.doi.org/10.3390/ijms232315188 |
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