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Drosophila as an Animal Model for Testing Plant-Based Immunomodulators
Allopathic medicines play a key role in the prevention and treatment of diseases. However, long-term consumption of these medicines may cause serious undesirable effects that harm human health. Plant-based medicines have emerged as alternatives to allopathic medicines because of their rare side effe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735809/ https://www.ncbi.nlm.nih.gov/pubmed/36499123 http://dx.doi.org/10.3390/ijms232314801 |
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author | Pratomo, Andre Rizky Salim, Emil Hori, Aki Kuraishi, Takayuki |
author_facet | Pratomo, Andre Rizky Salim, Emil Hori, Aki Kuraishi, Takayuki |
author_sort | Pratomo, Andre Rizky |
collection | PubMed |
description | Allopathic medicines play a key role in the prevention and treatment of diseases. However, long-term consumption of these medicines may cause serious undesirable effects that harm human health. Plant-based medicines have emerged as alternatives to allopathic medicines because of their rare side effects. They contain several compounds that have the potential to improve health and treat diseases in humans, including their function as immunomodulators to treat immune-related diseases. Thus, the discovery of potent and safe immunomodulators from plants is gaining considerable research interest. Recently, Drosophila has gained prominence as a model organism in evaluating the efficacy of plant and plant-derived substances. Drosophila melanogaster “fruit fly” is a well-known, high-throughput model organism that has been used to study different biological aspects of development and diseases for more than 110 years. Most developmental and cell signaling pathways and 75% of human disease-related genes are conserved between humans and Drosophila. Using Drosophila, one can easily examine the pharmacological effects of plants/plant-derived components by employing a variety of tests in flies, such as survival, anti-inflammatory, antioxidant, and cell death tests. This review focused on D. melanogaster’s potential for identifying immunomodulatory features associated with plants/plant-derived components. |
format | Online Article Text |
id | pubmed-9735809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97358092022-12-11 Drosophila as an Animal Model for Testing Plant-Based Immunomodulators Pratomo, Andre Rizky Salim, Emil Hori, Aki Kuraishi, Takayuki Int J Mol Sci Review Allopathic medicines play a key role in the prevention and treatment of diseases. However, long-term consumption of these medicines may cause serious undesirable effects that harm human health. Plant-based medicines have emerged as alternatives to allopathic medicines because of their rare side effects. They contain several compounds that have the potential to improve health and treat diseases in humans, including their function as immunomodulators to treat immune-related diseases. Thus, the discovery of potent and safe immunomodulators from plants is gaining considerable research interest. Recently, Drosophila has gained prominence as a model organism in evaluating the efficacy of plant and plant-derived substances. Drosophila melanogaster “fruit fly” is a well-known, high-throughput model organism that has been used to study different biological aspects of development and diseases for more than 110 years. Most developmental and cell signaling pathways and 75% of human disease-related genes are conserved between humans and Drosophila. Using Drosophila, one can easily examine the pharmacological effects of plants/plant-derived components by employing a variety of tests in flies, such as survival, anti-inflammatory, antioxidant, and cell death tests. This review focused on D. melanogaster’s potential for identifying immunomodulatory features associated with plants/plant-derived components. MDPI 2022-11-26 /pmc/articles/PMC9735809/ /pubmed/36499123 http://dx.doi.org/10.3390/ijms232314801 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pratomo, Andre Rizky Salim, Emil Hori, Aki Kuraishi, Takayuki Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title | Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title_full | Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title_fullStr | Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title_full_unstemmed | Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title_short | Drosophila as an Animal Model for Testing Plant-Based Immunomodulators |
title_sort | drosophila as an animal model for testing plant-based immunomodulators |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735809/ https://www.ncbi.nlm.nih.gov/pubmed/36499123 http://dx.doi.org/10.3390/ijms232314801 |
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