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When the Gates Swing Open Only: Arrhythmia Mutations That Target the Fast Inactivation Gate of Na(v)1.5
Na(v)1.5 is the main voltage-gated sodium channel found in cardiac muscle, where it facilitates the fast influx of Na(+) ions across the cell membrane, resulting in the fast depolarization phase—phase 0 of the cardiac action potential. As a result, it plays a major role in determining the amplitude...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735811/ https://www.ncbi.nlm.nih.gov/pubmed/36496974 http://dx.doi.org/10.3390/cells11233714 |