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Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis
Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including cardiovascular diseases, cerebrovascular disease and peripheral artery disease, which pose a big threat to human health. P...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735883/ https://www.ncbi.nlm.nih.gov/pubmed/36501028 http://dx.doi.org/10.3390/nu14234998 |
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author | Luo, Huiyu Chen, Junbin Su, Chuhong Zha, Longying |
author_facet | Luo, Huiyu Chen, Junbin Su, Chuhong Zha, Longying |
author_sort | Luo, Huiyu |
collection | PubMed |
description | Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including cardiovascular diseases, cerebrovascular disease and peripheral artery disease, which pose a big threat to human health. Phytochemicals are a variety of intermediate or terminal low molecular weight secondary metabolites produced during plant energy metabolism. Phytochemicals from plant foods (vegetables, fruits, whole grains) and traditional herb plants have been shown to exhibit multiple bioactivities which are beneficial for prevention and treatment against AS. Many types of phytochemicals including polyphenols, saponins, carotenoids, terpenoids, organic sulfur compounds, phytoestrogens, phytic acids and plant sterols have already been identified, among which saponins are a family of glycosidic compounds consisting of a hydrophobic aglycone (sapogenin) linked to hydrophilic sugar moieties. In recent years, studies have shown that saponins exhibit a number of biological activities such as anti-inflammation, anti-oxidation, cholesterol-lowering, immunomodulation, anti-platelet aggregation, etc., which are helpful in the prevention and treatment of AS. This review aims to summarize the recent advances in the anti-atherosclerotic bioactivities of saponins such as ginsenoside, soyasaponin, astra-galoside, glycyrrhizin, gypenoside, dioscin, saikosaponin, etc. |
format | Online Article Text |
id | pubmed-9735883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97358832022-12-11 Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis Luo, Huiyu Chen, Junbin Su, Chuhong Zha, Longying Nutrients Review Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including cardiovascular diseases, cerebrovascular disease and peripheral artery disease, which pose a big threat to human health. Phytochemicals are a variety of intermediate or terminal low molecular weight secondary metabolites produced during plant energy metabolism. Phytochemicals from plant foods (vegetables, fruits, whole grains) and traditional herb plants have been shown to exhibit multiple bioactivities which are beneficial for prevention and treatment against AS. Many types of phytochemicals including polyphenols, saponins, carotenoids, terpenoids, organic sulfur compounds, phytoestrogens, phytic acids and plant sterols have already been identified, among which saponins are a family of glycosidic compounds consisting of a hydrophobic aglycone (sapogenin) linked to hydrophilic sugar moieties. In recent years, studies have shown that saponins exhibit a number of biological activities such as anti-inflammation, anti-oxidation, cholesterol-lowering, immunomodulation, anti-platelet aggregation, etc., which are helpful in the prevention and treatment of AS. This review aims to summarize the recent advances in the anti-atherosclerotic bioactivities of saponins such as ginsenoside, soyasaponin, astra-galoside, glycyrrhizin, gypenoside, dioscin, saikosaponin, etc. MDPI 2022-11-24 /pmc/articles/PMC9735883/ /pubmed/36501028 http://dx.doi.org/10.3390/nu14234998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luo, Huiyu Chen, Junbin Su, Chuhong Zha, Longying Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title | Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title_full | Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title_fullStr | Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title_full_unstemmed | Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title_short | Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis |
title_sort | advances in the bioactivities of phytochemical saponins in the prevention and treatment of atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735883/ https://www.ncbi.nlm.nih.gov/pubmed/36501028 http://dx.doi.org/10.3390/nu14234998 |
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