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A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735927/ https://www.ncbi.nlm.nih.gov/pubmed/36499458 http://dx.doi.org/10.3390/ijms232315131 |
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author | Chighine, Alberto Corona, Andrea Catani, Gualtiero Conte, Celeste Demontis, Roberto Nioi, Matteo |
author_facet | Chighine, Alberto Corona, Andrea Catani, Gualtiero Conte, Celeste Demontis, Roberto Nioi, Matteo |
author_sort | Chighine, Alberto |
collection | PubMed |
description | We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological and immunohistochemical analyses allowed demonstrating a massive calcium redistribution consisting of an important osteolysis, especially from cranial bones and abnormal accumulation in lungs and other organs. Such physiopathology was driven by a primary hyperparathyroidism secondary to a parathyroid carcinoma as demonstrated by immunohistochemistry. This very rare case is furthermore characterised by a regular pregnancy course, ended with the birth of a healthy new-born. A complex interaction between pregnancy physiology and hyperparathyroidism might be hypothesised, determining the discrepancy between the relative long period of wellness and the tumultuous cascade occurred in the puerperium. |
format | Online Article Text |
id | pubmed-9735927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97359272022-12-11 A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium Chighine, Alberto Corona, Andrea Catani, Gualtiero Conte, Celeste Demontis, Roberto Nioi, Matteo Int J Mol Sci Case Report We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological and immunohistochemical analyses allowed demonstrating a massive calcium redistribution consisting of an important osteolysis, especially from cranial bones and abnormal accumulation in lungs and other organs. Such physiopathology was driven by a primary hyperparathyroidism secondary to a parathyroid carcinoma as demonstrated by immunohistochemistry. This very rare case is furthermore characterised by a regular pregnancy course, ended with the birth of a healthy new-born. A complex interaction between pregnancy physiology and hyperparathyroidism might be hypothesised, determining the discrepancy between the relative long period of wellness and the tumultuous cascade occurred in the puerperium. MDPI 2022-12-01 /pmc/articles/PMC9735927/ /pubmed/36499458 http://dx.doi.org/10.3390/ijms232315131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Chighine, Alberto Corona, Andrea Catani, Gualtiero Conte, Celeste Demontis, Roberto Nioi, Matteo A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title | A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title_full | A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title_fullStr | A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title_full_unstemmed | A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title_short | A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium |
title_sort | fatal case of metastatic pulmonary calcification during the puerperium |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735927/ https://www.ncbi.nlm.nih.gov/pubmed/36499458 http://dx.doi.org/10.3390/ijms232315131 |
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