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A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium

We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological...

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Autores principales: Chighine, Alberto, Corona, Andrea, Catani, Gualtiero, Conte, Celeste, Demontis, Roberto, Nioi, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735927/
https://www.ncbi.nlm.nih.gov/pubmed/36499458
http://dx.doi.org/10.3390/ijms232315131
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author Chighine, Alberto
Corona, Andrea
Catani, Gualtiero
Conte, Celeste
Demontis, Roberto
Nioi, Matteo
author_facet Chighine, Alberto
Corona, Andrea
Catani, Gualtiero
Conte, Celeste
Demontis, Roberto
Nioi, Matteo
author_sort Chighine, Alberto
collection PubMed
description We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological and immunohistochemical analyses allowed demonstrating a massive calcium redistribution consisting of an important osteolysis, especially from cranial bones and abnormal accumulation in lungs and other organs. Such physiopathology was driven by a primary hyperparathyroidism secondary to a parathyroid carcinoma as demonstrated by immunohistochemistry. This very rare case is furthermore characterised by a regular pregnancy course, ended with the birth of a healthy new-born. A complex interaction between pregnancy physiology and hyperparathyroidism might be hypothesised, determining the discrepancy between the relative long period of wellness and the tumultuous cascade occurred in the puerperium.
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spelling pubmed-97359272022-12-11 A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium Chighine, Alberto Corona, Andrea Catani, Gualtiero Conte, Celeste Demontis, Roberto Nioi, Matteo Int J Mol Sci Case Report We present an unusual case of a fatal respiratory failure in a young woman developed two weeks after she gave birth at home. Circumstantial and clinical features of the case were strongly suggestive for a ‘classical’ septic origin of the respiratory symptoms. Autopsy, together with histopathological and immunohistochemical analyses allowed demonstrating a massive calcium redistribution consisting of an important osteolysis, especially from cranial bones and abnormal accumulation in lungs and other organs. Such physiopathology was driven by a primary hyperparathyroidism secondary to a parathyroid carcinoma as demonstrated by immunohistochemistry. This very rare case is furthermore characterised by a regular pregnancy course, ended with the birth of a healthy new-born. A complex interaction between pregnancy physiology and hyperparathyroidism might be hypothesised, determining the discrepancy between the relative long period of wellness and the tumultuous cascade occurred in the puerperium. MDPI 2022-12-01 /pmc/articles/PMC9735927/ /pubmed/36499458 http://dx.doi.org/10.3390/ijms232315131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chighine, Alberto
Corona, Andrea
Catani, Gualtiero
Conte, Celeste
Demontis, Roberto
Nioi, Matteo
A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title_full A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title_fullStr A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title_full_unstemmed A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title_short A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium
title_sort fatal case of metastatic pulmonary calcification during the puerperium
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735927/
https://www.ncbi.nlm.nih.gov/pubmed/36499458
http://dx.doi.org/10.3390/ijms232315131
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